GAST - gastrin Gene
Also Known as GAS
Species: Homo sapiens
About GAST
This gene has 1 transcript (splice variant) and 91 orthologues. Restricted expression toward stomach (RPKM 4383.1).
Summary
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in Gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
GAST Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000805.5 | NP_000796.1 | gastrin preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7681836 | GOA |
GAST Protein Structure
Gastrin: Gastrin/cholecystokinin family (1 - 100)
- 0
- 101 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
gastrin |
|
GAST Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GAST | P01350 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
GAST | P01350 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
GAST | P01350 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
GAST | P01350 | CYB5R3 | Homo sapiens | P00387 | 32296183 | |
|
Intra
|
GAST | P01350 | CYB5R3 | Homo sapiens | P00387 | 32296183 | |
|
Intra
|
GAST | P01350 | ASPH | Homo sapiens | Q12797-6 | 32296183 | |
|
Intra
|
GAST | P01350 | PLP1 | Homo sapiens | P60201-2 | 32296183 | |
|
Intra
|
GAST | P01350 | PLP1 | Homo sapiens | P60201-2 | 32296183 | |
|
Intra
|
GAST | P01350 | PLP1 | Homo sapiens | P60201-2 | 32296183 | |
|
Intra
|
GAST | P01350 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
GAST | P01350 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
GAST | P01350 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
GAST | P01350 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
GAST | P01350 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
GAST | P01350 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
GAST | P01350 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
GAST | P01350 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
GAST | P01350 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
GAST | P01350 | AQP9 | Homo sapiens | O43315 | 32296183 | |
|
Intra
|
GAST | P01350 | AQP9 | Homo sapiens | O43315 | 32296183 | |
|
Intra
|
GAST | P01350 | LHFPL2 | Homo sapiens | Q6ZUX7 | 32296183 | |
|
Intra
|
GAST | P01350 | LHFPL2 | Homo sapiens | Q6ZUX7 | 32296183 | |
|
Intra
|
GAST | P01350 | LHFPL2 | Homo sapiens | Q6ZUX7 | 32296183 | |
|
Intra
|
GAST | P01350 | MMD | Homo sapiens | Q15546 | 32296183 | |
|
Intra
|
GAST | P01350 | MMD | Homo sapiens | Q15546 | 32296183 | |
|
Intra
|
GAST | P01350 | MMD | Homo sapiens | Q15546 | 32296183 | |
|
Intra
|
GAST | P01350 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
GAST | P01350 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
GAST | P01350 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
GAST | P01350 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GAST | P01350 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GAST | P01350 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GAST | P01350 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
GAST | P01350 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
GAST | P01350 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
GAST | P01350 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
GAST | P01350 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
GAST | P01350 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
GAST | P01350 | GOLM1 | Homo sapiens | Q8NBJ4 | 32296183 | |
|
Intra
|
GAST | P01350 | GOLM1 | Homo sapiens | Q8NBJ4 | 32296183 | |
|
Intra
|
GAST | P01350 | GOLM1 | Homo sapiens | Q8NBJ4 | 32296183 | |
|
Intra
|
GAST | P01350 | TF | Homo sapiens | P02787 | 19664057 | |
|
Intra
|
GAST | P01350 | TF | Homo sapiens | P02787 | 19664057 | |
|
Intra
|
GAST | P01350 | TF | Homo sapiens | P02787 | 19664057 | |
|
Intra
|
GAST | P01350 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GAST | P01350 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GAST | P01350 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GAST | P01350 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
GAST | P01350 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
GAST | P01350 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
GAST | P01350 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GAST | P01350 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GAST | P01350 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GAST | P01350 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
GAST | P01350 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
GAST | P01350 | KIR2DL3 | Homo sapiens | P43628 | 32296183 |
GAST Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P85974 | Gastrin Antibody (YA5666) | IHC-P, ICC/IF, ELISA | Human |
| HY-P85993 | Gastrin Antibody (YA5685) | IHC-P, ICC/IF, ELISA | Human |
| HY-P86036 | Gastrin Antibody (YA5728) | IHC-P, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Gastritis |
|
|
| Zollinger-Ellison Syndrome |
|
|
| Atrophic Gastritis |
|
|
| Duodenal Ulcer |
|
|
| Gastric Ulcer |
|
|
| Gastrinoma |
|
|
| Duodenitis |
|
|
| Duodenogastric Reflux |
|
|
| Gastroparesis |
|
|
| Peptic Ulcer Disease |
|
|
| Pernicious Anemia |
|
|
| Somatostatinoma |
|
|
| Vipoma |
|
|
| Islet Cell Tumor |
|
|
| Neuroendocrine Tumor |
|
|
| Postcholecystectomy Syndrome |
|
|
| Esophagitis |
|
|
| Pancreatic Endocrine Carcinoma |
|
|
| Glucagonoma |
|
|
| Gastritis, Familial Giant Hypertrophic |
|
|
| Pyloric Stenosis |
|
|
| Multiple Endocrine Neoplasia |
|
|
| Pancreatic Gastrinoma |
|
|
| Autoimmune Gastritis |
|
|
| Trichostrongyloidiasis |
|
|
| Gastrointestinal Neuroendocrine Benign Tumor |
|
|
| Endocrine Gland Cancer |
|
|
| Gastroesophageal Reflux |
|
|
| Gastrointestinal System Disease |
|
|
| Hypertrophic Pyloric Stenosis |
|
|
| Neuroendocrine Carcinoma |
|
|
| Multiple Endocrine Neoplasia, Type I |
|
|
| Duodenal Gastrinoma |
|
|
| Gastric Gastrinoma |
|
|
| Primary Hyperparathyroidism |
|
|
| Insulinoma |
|
|
| Displacement Of Cardia Through Esophageal Hiatus |
|
|
| Duodenum Disease |
|
|
| Haemonchiasis |
|
|
| Ostertagiasis |
|
|
| Vitamin B12 Deficiency |
|
|
| Gastric Body Carcinoma |
|
|
| Hyperparathyroidism |
|
|
| Dumping Syndrome |
|
|
| Peptic Esophagitis |
|
|
| Carcinoid Tumors, Intestinal |
|
|
| Autonomic Neuropathy |
|
|
| Microinvasive Gastric Cancer |
|
|
| Gastric Neuroendocrine Neoplasm |
|
|
| Pancreas Disease |
|
|
| Short Bowel Syndrome |
|
|
| Cholelithiasis |
|
|
| Duodenum Cancer |
|
|
| Pancreatic Cancer |
|
|
| Achalasia |
|
|
| Gastroduodenitis |
|
|
| Gastric Adenocarcinoma |
|
|
| Pancreatic Cholera |
|
|
| Non-Functioning Pancreatic Endocrine Tumor |
|
|
| Colorectal Cancer |
|
|
| Hernia, Hiatus |
|
|
| Mucinous Ovarian Cystadenoma |
|
|
| Endocrine Pancreas Disease |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Acinar Cell Carcinoma |
|
|
| Hyperinsulinemic Hypoglycemia, Familial, 2 |
|
|
| Granulomatous Gastritis |
|
|
| Small Intestine Cancer |
|
|
| Constipation |
|
|
| Gastric Cancer |
|
|
| Cystinosis |
|
|
| Peripheral Vascular Disease |
|
|
| Hypoglycemia |
|
|
| Pancreatic Cystadenoma |
|
|
| Diarrhea |
|
|
| Gastrointestinal Neuroendocrine Tumor |
|
|
| Macrocytic Anemia |
|
|
| Bile Reflux |
|
|
| Gastrointestinal Carcinoma |
|
|
| Peptic Ulcer Perforation |
|
|
| Duodenal Somatostatinoma |
|
|
| Lymphocytic Gastritis |
|
|
| Skin Lipoma |
|
|
| Benign Ileal Neoplasm |
|
|
| Functional Gastric Disease |
|
|
| Gastric Antral Vascular Ectasia |
|
|
| Barrett Esophagus |
|
|
| Rectum Neuroendocrine Neoplasm |
|
|
| Pancreatic Somatostatinoma |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Thyroid Gland Cancer |
|
|
| Cardia Cancer |
|
|
| Colon Neuroendocrine Neoplasm |
|
|
| Vitamin Metabolic Disorder |
|
|
| Neurogenic Bowel |
|
|
| Fungal Gastritis |
|
|
| Thyroid Gland Medullary Carcinoma |
|
|
| Parathyroid Gland Disease |
|
|
| Hyperinsulinemic Hypoglycemia |
|
|
| Nutritional Deficiency Disease |
|
|
| Secretory Diarrhea |
|
|
| Tropical Sprue |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Baritosis |
|
|
| Parathyroid Adenoma |
|
|
| Glossitis |
|
|
| Serotonin Syndrome |
|
|
| Esophageal Neuroendocrine Tumor |
|
|
| Meckel Diverticulum |
|
|
| Gastroduodenal Crohn'S Disease |
|
|
| Melon Allergy |
|
|
| Strabismus |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Deficiency Anemia |
|
|
| Endometrial Small Cell Carcinoma |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Diabetes Mellitus |
|
|
| Colonic Benign Neoplasm |
|
|
| Celiac Disease 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | GAST | VGNC | VGNC:41121 |
| Mus musculus | GAST | MGD | MGI:104768 |
| Bos taurus | GAST | VGNC | VGNC:29264 |
| Rattus norvegicus | GAST | RGD | RGD:2662 |
| Others | GAST | NCBI |