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BCL2L13 - BCL2 like 13 Gene

Also Known as MIL1; BCL-RAMBO; Bcl2-L-13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23786

About BCL2L13

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,628,877-17,730,855 (from NCBI)

This gene has 17 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in fat (RPKM 9.5), adrenal (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in Apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

BCL2L13 Products (12)

mRNA	Protein	Name
NM_001270726.1	NP_001257655.1	bcl-2-like protein 13 isoform b
NM_001270727.1	NP_001257656.1	bcl-2-like protein 13 isoform c
NM_001270728.2	NP_001257657.1	bcl-2-like protein 13 isoform d
NM_001270729.2	NP_001257658.1	bcl-2-like protein 13 isoform e
NM_001270730.2	NP_001257659.1	bcl-2-like protein 13 isoform e
NM_001270731.2	NP_001257660.1	bcl-2-like protein 13 isoform e
NM_001270732.2	NP_001257661.1	bcl-2-like protein 13 isoform f
NM_001270733.2	NP_001257662.1	bcl-2-like protein 13 isoform g
NM_001270734.2	NP_001257663.1	bcl-2-like protein 13 isoform h
NM_001270735.2	NP_001257664.1	bcl-2-like protein 13 isoform i
NM_001363824.1	NP_001350753.1	bcl-2-like protein 13 isoform j
NM_015367.4	NP_056182.2	bcl-2-like protein 13 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in membrane	IDA IDA: Inferred from direct assay	11262395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2L13 Protein Structure

Bcl-2

0
100
200
300
400
485 a.a.

Protein Preferred Names	Protein Names
bcl-2-like protein 13	BCL2-like 13 (apoptosis facilitator)

BCL2L13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	BCL2L13	Q9BXK5	VAMP4	Homo sapiens	O75379-2	Validated Y2H	25416956
Intra	BCL2L13	Q9BXK5	VAMP4	Homo sapiens	O75379-2	Y2H Array	25416956
Intra	BCL2L13	Q9BXK5	VAMP4	Homo sapiens	O75379-2	Y2H Prey Pooling	25416956
Intra	BCL2L13	Q9BXK5	BET1	Homo sapiens	Q53XK0	Y2H Prey Pooling	25416956
Intra	BCL2L13	Q9BXK5	TMEM128	Homo sapiens	Q5BJH2	Y2H Prey Pooling	25416956
Intra	BCL2L13	Q9BXK5	TMEM128	Homo sapiens	Q5BJH2	Validated Y2H	25416956
Intra	BCL2L13	Q9BXK5	TMEM128	Homo sapiens	Q5BJH2	Y2H Array	25416956
Intra	BCL2L13	Q9BXK5	DEFB127	Homo sapiens	Q9H1M4	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	BCL2L13	Q9BXK5	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	BCL2L13	Q9BXK5	NINJ2	Homo sapiens	Q9NZG7	Y2H Array	25416956
Intra	BCL2L13	Q9BXK5	NINJ2	Homo sapiens	Q9NZG7	Y2H Prey Pooling	25416956
Intra	BCL2L13	Q9BXK5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	BCL2L13	Q9BXK5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	BCL2L13	Q9BXK5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	BCL2L13	Q9BXK5	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TM6SF2	Homo sapiens	Q9BZW4	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	BCL2L13	Q9BXK5	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	BCL2L13	Q9BXK5	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	BCL2L13	Q9BXK5	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	BCL2L13	Q9BXK5	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	BCL2L13	Q9BXK5	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	BCL2L13	Q9BXK5	TMUB2	Homo sapiens	Q71RG4	Validated Y2H	25416956
Intra	BCL2L13	Q9BXK5	TMUB2	Homo sapiens	Q71RG4	Y2H Array	25416956
Intra	BCL2L13	Q9BXK5	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	BCL2L13	Q9BXK5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	BCL2L13	Q9BXK5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	BCL2L13	Q9BXK5	VAMP3	Homo sapiens	Q15836	Y2H Prey Pooling	25416956
Intra	BCL2L13	Q9BXK5	VAMP3	Homo sapiens	Q15836	Validated Y2H	25416956
Intra	BCL2L13	Q9BXK5	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	BCL2L13	Q9BXK5	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	BCL2L13	Q9BXK5	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	BCL2L13	Q9BXK5	SOD1	Homo sapiens	P00441	Anti Tag CoIP	28514442
Intra	BCL2L13	Q9BXK5	SOD1	Homo sapiens	P00441	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

BCL2L13 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P89862	Bcl-rambo Antibody (YA9206)	WB, ICC/IF, IF-Tissue, IP	human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01431	BCL2L13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149623	Bcl-2-IN-13	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BCL2L13	VGNC	VGNC:38409
Macaca mulatta	BCL2L13	VGNC	VGNC:84544
Felis catus	BCL2L13	VGNC	VGNC:60084
Rattus norvegicus	BCL2L13	RGD	RGD:1306985
Mus musculus	BCL2L13	MGD	MGI:2136959
Bos taurus	BCL2L13	VGNC	VGNC:56193
Others	BCL2L13	NCBI