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TMEM14C - transmembrane protein 14C Gene

Also Known as NET26; C6orf53; HSPC194; MSTP073; bA421M1.6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51522

About TMEM14C

Cytogenetic location: 6p24.2 Genomic coordinates (GRCh38): 6:10,723,070-10,731,127 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 305 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 65.2), adrenal (RPKM 55.4) and 25 other tissues.

Summary

Predicted to be involved in mitochondrial transport. Predicted to act upstream of or within erythrocyte differentiation and regulation of heme biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM14C Products (2)

mRNA	Protein	Name
NM_001165258.2	NP_001158730.1	transmembrane protein 14C
NM_016462.4	NP_057546.1	transmembrane protein 14C

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM14C Protein Structure

Tmemb_14

0
100
112 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 14C

TMEM14C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM14C	Q9P0S9	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	NCAPH2	Homo sapiens	Q6IBW4-4	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	NCAPH2	Homo sapiens	Q6IBW4-4	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	NCR3LG1	Homo sapiens	Q68D85	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	NCR3LG1	Homo sapiens	Q68D85	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	MARCHF8	Homo sapiens	Q5T0T0	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	MARCHF8	Homo sapiens	Q5T0T0	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	SYT1	Homo sapiens	P21579	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM14C	Q9P0S9	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	TMEM14C	Q9P0S9	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	TMEM14C	Q9P0S9	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	TMEM14C	Q9P0S9	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TMEM14C	Q9P0S9	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183
Intra	TMEM14C	Q9P0S9	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Trachea Adenoid Cystic Carcinoma	Tracheal Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma Of Trachea
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris
Tracheal Cancer	Tracheal Carcinoma Malignant Neoplasm Of Trachea Tracheal Neoplasms Pancoast Tumor Pulmonary Sulcus Neoplasm Pancoast Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14671	TMEM14C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TMEM14C	MGD	MGI:1913404
Rattus norvegicus	TMEM14C	RGD	RGD:621692
Others	TMEM14C	NCBI