MARCHF8 - membrane associated ring-CH-type finger 8 Gene

Also Known as MIR; CMIR; c-MIR; MARCH8; RNF178; MARCH-VIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 220972

Summary

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH Enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Ubiquitous expression in testis (RPKM 18.4), bone marrow (RPKM 12.0) and 25 other tissues.

MARCHF8 Products (5)

mRNA Protein Name
NM_001002266.3 NP_001002266.1 E3 ubiquitin-protein ligase MARCHF8 isoform a
NM_001282866.2 NP_001269795.1 E3 ubiquitin-protein ligase MARCHF8 isoform b
NM_001401645.1 NP_001388574.1 E3 ubiquitin-protein ligase MARCHF8 isoform b
NM_001401646.1 NP_001388575.1 E3 ubiquitin-protein ligase MARCHF8 isoform b
NM_145021.6 NP_659458.2 E3 ubiquitin-protein ligase MARCHF8 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14722266 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
19117940 GOA
Cellular Component GO Annotation Evidence Références Source
located in endosome IDA
IDA: Inferred from direct assay
14722266 GOA
located in lysosome IDA
IDA: Inferred from direct assay
14722266 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCHF8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MARCHF8 Q5T0T0 FA2H Homo sapiens Q7L5A8
Validated Y2H
32296183
Intra
MARCHF8 Q5T0T0 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08143 MARCHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08144 MARCHF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown