ZDHHC15 - zinc finger DHHC-type palmitoyltransferase 15 Gene

Also Known as MRX91; DHHC15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 158866

About ZDHHC15

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:75,368,427-75,523,037 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 1.4), thyroid (RPKM 0.9) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ZDHHC15 Products (3)

mRNA Protein Name
NM_001146256.2 NP_001139728.1 palmitoyltransferase ZDHHC15 isoform 2
NM_001146257.2 NP_001139729.1 palmitoyltransferase ZDHHC15 isoform 3
NM_144969.3 NP_659406.1 palmitoyltransferase ZDHHC15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
23034182 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein-cysteine S-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
18817523 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in peptidyl-L-cysteine S-palmitoylation IDA
IDA: Inferred from direct assay
18817523 GOA
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
18817523 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
23034182 GOA
involved in protein targeting to Golgi apparatus IMP
IMP: Inferred from mutant phenotype
18817523 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16647879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC15 Protein Structure

DHHC

DHHC: DHHC palmitoyltransferase (70 - 247)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

palmitoyltransferase ZDHHC15

  • DHHC-15

ZDHHC15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ZDHHC15 Q96MV8 LSMEM1 Homo sapiens Q8N8F7
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 LSMEM1 Homo sapiens Q8N8F7
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TMEFF2 Homo sapiens Q9UIK5
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TMEFF2 Homo sapiens Q9UIK5
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 TMEFF2 Homo sapiens Q9UIK5
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 TBXA2R Homo sapiens Q0VAB0
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TBXA2R Homo sapiens Q0VAB0
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 MCEMP1 Homo sapiens Q8IX19
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 MCEMP1 Homo sapiens Q8IX19
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TNFRSF10B Homo sapiens O14763
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 TNFRSF10B Homo sapiens O14763
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
ZDHHC15 Q96MV8 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
ZDHHC15 Q96MV8 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra
ZDHHC15 Q96MV8 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Diplegia

  • Diplegic Infantile Cerebral Palsy

  • Little'S Disease

  • Cerebral Palsy

  • Cerebral Spastic Infantile Paralysis

  • Infantile Diplegic Cerebral Palsy

  • Infantile Spastic Cerebral Palsy

  • Littles Disease

  • Spastic Cerebral Palsy
Non-Syndromic X-Linked Intellectual Disability 91

  • Mrx91
Non-Syndromic X-Linked Intellectual Disability 98

  • Mrx98

  • X-Linked Mental Retardation 98
Non-Syndromic X-Linked Intellectual Disability 58

  • Mrx58
Cerebral Palsy, Ataxic, Autosomal Recessive

  • Ataxic Cerebral Palsy

  • Acp

  • Hypotonic Cerebral Palsy

  • Cerebral Palsy Ataxic

  • Cerebral Palsy, Atonic

  • Congenital Cerebral Palsy With Ataxia

  • Ataxic Cerebral Paralysis

  • Ataxia With Cerebral Palsy

  • Cerebral Infantile Diataxia
Tonne-Kalscheuer Syndrome

  • TOKAS

  • Mrx61

  • Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia

  • Mental Retardation, X-Linked 61

  • X-Linked Mental Retardation 61
Inflammatory Bowel Disease 22

  • IBD22
Cataract 40

  • CTRCT40

  • Cataract 40 With Or Without Microcornea

  • Cct

  • Cataract, Congenital, X-Linked

  • Cataract 40, X-Linked

  • Cataract, Congenital, With Microcornea Or Slight Microphthalmia

  • Cxn

  • Cataract, Congenital Total, With Posterior Sutural Opacities In Heterozygotes

  • Cataract 40 X-Linked

  • Cataract Congenital X-Linked

  • Cataract, Total Congenital

  • Cataract, Total Congenital With Posterior Sutural Opacities In Heterozygotes

  • Congenital Total Cataract With Posterior Sutural Opacities In Heterozygotes

  • X-Linked Congenital Cataract

  • Cataract, Type 40
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS16015 ZDHHC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZDHHC15 VGNC VGNC:37130
Canis familiaris ZDHHC15 VGNC VGNC:48581
Mus musculus ZDHHC15 MGD MGI:1915336
Macaca mulatta ZDHHC15 VGNC VGNC:79245
Rattus norvegicus ZDHHC15 RGD RGD:1562075
Felis catus ZDHHC15 VGNC VGNC:67204
Others ZDHHC15 NCBI