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TMEM222 - transmembrane protein 222 Gene

Also Known as C1orf160; NEDMOSBA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84065

About TMEM222

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,322,163-27,336,400 (from NCBI)

This gene has 11 transcripts (splice variants), 268 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 11.2), testis (RPKM 10.1) and 25 other tissues.

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM222 Products (1)

mRNA	Protein	Name
NM_032125.3	NP_115501.2	transmembrane protein 222

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	33824500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM222 Protein Structure

DUF778

0
100
208 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 222

TMEM222 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM222	Q9H0R3	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	NCR3LG1	Homo sapiens	Q68D85	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	NCR3LG1	Homo sapiens	Q68D85	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	LRRC59	Homo sapiens	Q96AG4	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM222	Q9H0R3	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	TMEM222	Q9H0R3	ERG28	Homo sapiens	Q9UKR5	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	ERG28	Homo sapiens	Q9UKR5	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM222	Q9H0R3	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	TMEM222	Q9H0R3	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM222	Q9H0R3	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TMEM222	Q9H0R3	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities	NEDMOSBA
Brachial Plexus Neuritis	Brachial Neuritis Parsonage-Aldren-Turner Syndrome
Osteosclerotic Myeloma
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14701	TMEM222 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM222	VGNC	VGNC:36043
Macaca mulatta	TMEM222	VGNC	VGNC:79491
Canis familiaris	TMEM222	VGNC	VGNC:47536
Felis catus	TMEM222	VGNC	VGNC:66317
Rattus norvegicus	TMEM222	RGD	RGD:1304793
Mus musculus	TMEM222	MGD	MGI:1098568
Others	TMEM222	NCBI