LRRC59 - leucine rich repeat containing 59 Gene

Also Known as p34; PRO1855

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55379

About LRRC59

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,381,238-50,397,523 (from NCBI)

This gene has 3 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in colon (RPKM 47.1), stomach (RPKM 37.6) and 25 other tissues.

Summary

Enables RNA binding activity and Cadherin binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Located in endoplasmic reticulum and mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022]

LRRC59 Products (1)

mRNA Protein Name
NM_018509.4 NP_060979.2 leucine-rich repeat-containing protein 59

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
18063578 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC59 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (42 - 61)

LRR_8

LRR_8: Leucine rich repeat (62 - 120)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 59

  • ribosome-binding protein p34

LRRC59 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRC59 Q96AG4 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
LRRC59 Q96AG4 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra
LRRC59 Q96AG4 TMEM97 Homo sapiens Q5BJF2
Y2H Prey Pooling
32296183
Intra
LRRC59 Q96AG4 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
LRRC59 Q96AG4 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
LRRC59 Q96AG4 CMTM3 Homo sapiens Q96MX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ogden Syndrome

  • OGDNS

  • N-Terminal Acetyltransferase Deficiency

  • NATD

  • N-Alpha-Acetyltransferase

  • X-Linked Malformation And Infantile Lethality Syndrome

  • Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07825 LRRC59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRRC59 MGD MGI:2138133
Canis familiaris LRRC59 VGNC VGNC:55628
Bos taurus LRRC59 VGNC VGNC:55843
Felis catus LRRC59 VGNC VGNC:97484
Macaca mulatta LRRC59 VGNC VGNC:81436
Rattus norvegicus LRRC59 RGD RGD:1305092
Others LRRC59 NCBI