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CMTM3 - CKLF like MARVEL transmembrane domain containing 3 Gene

Also Known as BNAS2; CKLFSF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123920

About CMTM3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,603,996-66,613,892 (from NCBI)

This gene has 15 transcripts (splice variants), 204 orthologues and 14 paralogues. Broad expression in testis (RPKM 24.7), placenta (RPKM 16.7) and 24 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CMTM3 Products (4)

mRNA	Protein	Name
NM_001363918.2	NP_001350847.1	CKLF-like MARVEL transmembrane domain-containing protein 3
NM_001363923.2	NP_001350852.1	CKLF-like MARVEL transmembrane domain-containing protein 3
NM_144601.5	NP_653202.1	CKLF-like MARVEL transmembrane domain-containing protein 3
NM_181553.4	NP_853531.1	CKLF-like MARVEL transmembrane domain-containing protein 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	28428220	GOA
located in cytosol	IDA IDA: Inferred from direct assay	28428220	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM3 Protein Structure

MARVEL

0
100
182 a.a.

Protein Preferred Names	Protein Names
CKLF-like MARVEL transmembrane domain-containing protein 3	chemokine-like factor superfamily member 3

CMTM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CMTM3	Q96MX0	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	CMTM3	Q96MX0	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	CMTM3	Q96MX0	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	CMTM3	Q96MX0	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CMTM3	Q96MX0	IKBIP	Homo sapiens	Q70UQ0-4	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	IKBIP	Homo sapiens	Q70UQ0-4	Y2H Array	32296183
Intra	CMTM3	Q96MX0	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CMTM3	Q96MX0	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	CMTM3	Q96MX0	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	CMTM3	Q96MX0	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CMTM3	Q96MX0	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	CMTM3	Q96MX0	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	STMN4	Homo sapiens	Q9H169-2	Y2H Array	32296183
Intra	CMTM3	Q96MX0	STMN4	Homo sapiens	Q9H169-2	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	STMN4	Homo sapiens	Q9H169-2	Validated Y2H	32296183
Intra	CMTM3	Q96MX0	F13A1	Homo sapiens	P00488	Validated Y2H	32814053
Intra	CMTM3	Q96MX0	F13A1	Homo sapiens	P00488	Y2H Array	32814053
Intra	CMTM3	Q96MX0	F13A1	Homo sapiens	P00488	Y2H Pooling	32814053
Intra	CMTM3	Q96MX0	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	CMTM3	Q96MX0	LRRC59	Homo sapiens	Q96AG4	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	CMTM3	Q96MX0	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	CMTM3	Q96MX0	APOA5	Homo sapiens	Q6Q788	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	APOA5	Homo sapiens	Q6Q788	Y2H Array	32296183
Intra	CMTM3	Q96MX0	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	CMTM3	Q96MX0	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	CMTM3	Q96MX0	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	MOB1A	Homo sapiens	Q9H8S9	Y2H Array	25416956
Intra	CMTM3	Q96MX0	MOB1A	Homo sapiens	Q9H8S9	Y2H Prey Pooling	25416956
Intra	CMTM3	Q96MX0	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	CMTM3	Q96MX0	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	CMTM3	Q96MX0	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
Intra	CMTM3	Q96MX0	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	CMTM3	Q96MX0	MOB3C	Homo sapiens	Q70IA8	Y2H Array	25416956
Intra	CMTM3	Q96MX0	MOB3C	Homo sapiens	Q70IA8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02865	CMTM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CMTM3	VGNC	VGNC:39381
Mus musculus	CMTM3	MGD	MGI:2447162
Bos taurus	CMTM3	VGNC	VGNC:27483
Macaca mulatta	CMTM3	VGNC	VGNC:71215
Felis catus	CMTM3	VGNC	VGNC:61000
Rattus norvegicus	CMTM3	RGD	RGD:1308763
Others	CMTM3	NCBI