APOA5 - apolipoprotein A5 Gene

Also Known as RAP3; APOAV

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116519

About APOA5

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,789,367-116,792,420 (from NCBI)

This gene has 4 transcripts (splice variants), 99 orthologues, 3 paralogues and is associated with 5 phenotypes. Restricted expression toward liver (RPKM 62.5).

Summary

The protein encoded by this gene is an Apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the Apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

APOA5 Products (3)

mRNA	Protein	Name
NM_001166598.2	NP_001160070.1	apolipoprotein A-V precursor
NM_001371904.1	NP_001358833.1	apolipoprotein A-V precursor
NM_052968.5	NP_443200.2	apolipoprotein A-V precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	16806135	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	15178420	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	15878877	GOA
enables lipase activator activity	IMP IMP: Inferred from mutant phenotype	15178420	GOA
enables lipase binding	IPI IPI: Inferred from physical interaction	15178420	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	12810715	GOA
enables lipoprotein lipase activator activity	IDA IDA: Inferred from direct assay	18635818	GOA
enables lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	18635818	GOA
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	17326667	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	16806135	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	12810715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acylglycerol homeostasis	IDA IDA: Inferred from direct assay	11588264	GOA
involved in acylglycerol homeostasis	IMP IMP: Inferred from mutant phenotype	15178420	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	19121291	GOA
involved in lipid transport	IDA IDA: Inferred from direct assay	15178420	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	18635818	GOA
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	16806135	GOA
involved in positive regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	15178420	GOA
involved in positive regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	18635818	GOA
involved in positive regulation of very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	18635818	GOA
involved in tissue regeneration	IEP IEP: Inferred from expression pattern	11577099	GOA
involved in triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	15178420	GOA
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	19121291	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	18635818	GOA
involved in triglyceride metabolic process	IDA IDA: Inferred from direct assay	11588264	GOA
involved in triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	12417525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chylomicron	IDA IDA: Inferred from direct assay	15528295	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	11577099	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18635818	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	15528295	GOA
NOT part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	15528295	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	15528295	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOA5 Protein Structure

Apolipoprotein

0
100
200
300
366 a.a.

Protein Preferred Names	Protein Names
apolipoprotein A-V	apo-AV

APOA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOA5	Q6Q788	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	32296183
Intra	APOA5	Q6Q788	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	APOA5	Q6Q788	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	APOA5	Q6Q788	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	APOA5	Q6Q788	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	APOA5	Q6Q788	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	APOA5	Q6Q788	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	APOA5	Q6Q788	ACSF2	Homo sapiens	Q96CM8	Validated Y2H	32296183
Intra	APOA5	Q6Q788	SELENOS	Homo sapiens	Q9BQE4	Validated Y2H	32296183
Intra	APOA5	Q6Q788	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183
Intra	APOA5	Q6Q788	TMEM43	Homo sapiens	Q9BTV4	Validated Y2H	32296183
Intra	APOA5	Q6Q788	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	APOA5	Q6Q788	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

APOA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84641	Apoa5 Antibody (YA4338)	WB, ELISA	Human
HY-P84641A	Apoa5 Antibody (YA4338)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Hypertriglyceridemia 1	Hypertriglyceridemia Hypertriglyceridemia, Familial Hypertriglyceridemia, Susceptibility To HYTG1 FHTR Hypertriglyceridemias Familial
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia
Familial Apolipoprotein A5 Deficiency	Familial Apoa5 Deficiency Familial Apolipoprotein A-V Deficiency
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Hyperlipoproteinemia, Type Iii	Hyperlipoproteinemia Type Iii Broad-Betalipoproteinemia Floating-Betalipoproteinemia Familial Type 3 Hyperlipoproteinemia Broad Beta Disease Familial Hyperbeta- And Prebetalipoproteinemia Familial Hypercholesterolemia With Hyperlipemia Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis Coronary Artery Disease, Severe, Susceptibility To Coronary Artery Disease, Severe Hyperlipidemia Type 3 Familial Dysbetalipoproteinemia Hyperlipoproteinemia Type 3 Coronary Artery Disease Apolipoprotein E, Deficiency Or Defect Of Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D Carbohydrate Induced Hyperlipemia Familial Hypercholesterolaemia With Hyperlipaemia Remnant Hyperlipidemia Remnant Removal Disease Dysbetalipoproteinemia Broad-Beta Disease Familial Dyslipidemia Type 3 Hlp Type 3 Remnant Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iii CAD Hyperlipoproteinemia 3 HLPP3 Deficiency Or Defect Of Apolipoprotein E Dysbetalipoproteinemia Due To Defect In Apolipoprotein E Coronary Arteriosclerosis Coronary Heart Disease
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Hyperlipoproteinemia, Type Iv	Hyperlipoproteinemia Type Iv Carbohydrate-Inducible Hyperlipemia Endogenous Hyperlipidaemia Familial Hypertriglyceridemia Fredrickson Type Iv Hyperlipoproteinemia Fredrickson Type Iv Lipidaemia Fredrickson Type Iv Lipidemia Vldl Hyperlipoproteinemia Hyperlipoproteinemia Type 4 Carbohydrate Inducible Hyperlipemia Familial Type Iv Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iv
Pancreatitis	Mumps Pancreatitis
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Diabetes Mellitus	Diabetes
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Familial Lipoprotein Lipase Deficiency	Familial Lpl Deficiency Familial Hyperchylomicronemia Hyperlipoproteinemia Type I Familial Hyperlipoproteinemia Type I Hyperchylomicronemia Burger-Grutz Syndrome Endogenous Hypertriglyceridaemia Familial Fat-Induced Hypertriglyceridemia Lipd Deficiency Lpl Deficiency Lipase D Deficiency Lipoprotein Lipase Deficiency, Familial Familial Chylomicronemia Syndrome Fredrickson Type I Hyperlipoproteinemia Fredrickson Type I Lipaemia Hypercholesterinaemic Xanthomatosis Mixed Hyperglyceridemia Lipoprotein Lipase Deficiency Type I Hyperlipoproteinemia Hyperlipoproteinemia Type Ia Familial Hyperlipo-Proteinemia Type 1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Lipase Deficiency, Combined	Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency Lpl And Htgl Deficiency Lpl And Hl Deficiency Familial Lipase Maturation Factor 1 Deficiency Lipase Deficiency Combined Combined Lipase Deficiency Familial Lmf1 Deficiency CLD
Apolipoprotein C-Iii Deficiency	Hyperalphalipoproteinemia 2 HALP2
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Sitosterolemia	Phytosterolemia Beta-Sitosterolemia Plant Sterol Storage Disease Phytosterolæmia Sitosterolæmia Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body Phytosterolaemia Sitosterolaemia Sitosterolemia With Xanthomatosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00832	APOA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19171	Apoa5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25660	Apoa5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APOA5	VGNC	VGNC:107423
Bos taurus	APOA5	VGNC	VGNC:26025
Felis catus	APOA5	VGNC	VGNC:59853
Canis familiaris	APOA5	VGNC	VGNC:37993
Mus musculus	APOA5	MGD	MGI:1913363
Rattus norvegicus	APOA5	RGD	RGD:70903
Others	APOA5	NCBI