APOA5 - apolipoprotein A5 Gene

Homo sapiens

Also known as RAP3; APOAV

Gene ID: 116519 | Gene type: protein coding

About APOA5

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,789,367-116,792,420 (from NCBI)

This gene has 4 transcripts (splice variants), 99 orthologues, 3 paralogues and is associated with 5 phenotypes. Restricted expression toward liver (RPKM 62.5).

Summary

The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

APOA5 Products(3)

mRNA	Protein	Name
NM_001166598.2	NP_001160070.1	apolipoprotein A-V precursor
NM_001371904.1	NP_001358833.1	apolipoprotein A-V precursor
NM_052968.5	NP_443200.2	apolipoprotein A-V precursor

APOA5 Protein Structure

Apolipoprotein

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

apolipoprotein A-V

apo-AV

Related Diseases

Diseases

Alias

Hypertriglyceridemia 1

Hypertriglyceridemia	Hypertriglyceridemia, Familial
Hypertriglyceridemia, Susceptibility To	HYTG1
FHTR	Hypertriglyceridemias Familial

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V	Hyperchylomicronemia, Late-Onset
Familial Type 5 Hyperlipoproteinemia	Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipidemia, Type V	Hyperlipemia, Mixed
Hyperlipemia, Combined Fat And Carbohydrate-Induced	Familial Hyperlipoproteinemia Type V
Fredrickson Type V Lipaemia	Hyperlipoproteinemia Type 5
Hyperchylomicronemia Late Onset	Hyperlipemia Combined Fat And Carbohydrate-Induced
Hyperlipemia Mixed	Hyperlipidemia Type V
Mixed Hyperlipemia	Type V Hyperlipoproteinemia
Hyperlipoproteinemia 5	HLPP5
Hyperlipidemia, Familial Combined	Mixed Hyperlipidemia

Familial Apolipoprotein A5 Deficiency

Familial Apoa5 Deficiency

Familial Apolipoprotein A-V Deficiency

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Hyperlipoproteinemia, Type Iii

Hyperlipoproteinemia Type Iii	Broad-Betalipoproteinemia
Floating-Betalipoproteinemia	Familial Type 3 Hyperlipoproteinemia
Broad Beta Disease	Familial Hyperbeta- And Prebetalipoproteinemia
Familial Hypercholesterolemia With Hyperlipemia	Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis
Coronary Artery Disease, Severe, Susceptibility To	Coronary Artery Disease, Severe
Hyperlipidemia Type 3	Familial Dysbetalipoproteinemia
Hyperlipoproteinemia Type 3	Coronary Artery Disease
Apolipoprotein E, Deficiency Or Defect Of	Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D
Carbohydrate Induced Hyperlipemia	Familial Hypercholesterolaemia With Hyperlipaemia
Remnant Hyperlipidemia	Remnant Removal Disease
Dysbetalipoproteinemia	Broad-Beta Disease
Familial Dyslipidemia Type 3	Hlp Type 3
Remnant Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iii
CAD	Hyperlipoproteinemia 3
HLPP3	Deficiency Or Defect Of Apolipoprotein E
Dysbetalipoproteinemia Due To Defect In Apolipoprotein E	Coronary Arteriosclerosis
Coronary Heart Disease

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Pancreatitis

Mumps Pancreatitis

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Diabetes Mellitus

Diabetes

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia	Familial Hypobetalipoproteinemia 1
Familial Hypobetalipoproteinemia	FHBL1
Hypobetalipoproteinemia, Familial	Fhbl
Acanthocytosis With Hypobetalipoproteinemia	Hypobetalipoproteinemias
Hypobetalipoproteinemia, Normotriglyceridemic	Hypo-Beta-Lipoproteinemia
Hypobetalipoprotéinemia, Familial	Normotriglyceridemic Hypobetalipoproteinemia
Hypobetalipoproteinemia, Familial, Type 1

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency	Familial Hyperchylomicronemia
Hyperlipoproteinemia Type I	Familial Hyperlipoproteinemia Type I
Hyperchylomicronemia	Burger-Grutz Syndrome
Endogenous Hypertriglyceridaemia	Familial Fat-Induced Hypertriglyceridemia
Lipd Deficiency	Lpl Deficiency
Lipase D Deficiency	Lipoprotein Lipase Deficiency, Familial
Familial Chylomicronemia Syndrome	Fredrickson Type I Hyperlipoproteinemia
Fredrickson Type I Lipaemia	Hypercholesterinaemic Xanthomatosis
Mixed Hyperglyceridemia	Lipoprotein Lipase Deficiency
Type I Hyperlipoproteinemia	Hyperlipoproteinemia Type Ia
Familial Hyperlipo-Proteinemia Type 1

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Lipase Deficiency, Combined

Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency	Lpl And Htgl Deficiency
Lpl And Hl Deficiency	Familial Lipase Maturation Factor 1 Deficiency
Lipase Deficiency Combined	Combined Lipase Deficiency
Familial Lmf1 Deficiency	CLD

Apolipoprotein C-Iii Deficiency

Hyperalphalipoproteinemia 2

HALP2

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Hypoalphalipoproteinemia, Primary, 1

Familial Hdl Deficiency	Fha
High Density Lipoprotein Deficiency	Familial Hypoalphalipoproteinemia
Hypoalphalipoproteinemia, Familial	Hdld
Fhd	Hdl Deficiency, Type 2
Primary Hypoalphalipoproteinemia 1	Hdl Cholesterol, Low Serum
Hdlc	Hdl Deficiency, Familial, 1
Hypoalphalipoproteinemia, Primary	Low Serum Hdl Cholesterol
Primary Hypoalphalipoproteinemia	FHA1
Hdld2	High Density Lipoprotein Deficiency 2
Hypoalphalipoproteinemias	Apolipoprotein A-I Deficiency

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Hypolipoproteinemia

Hypolipoproteinaemia	Lipoprotein Deficiencies
Lipoprotein Disorder	Hypolipoproteinemias
Lipoprotein	Lipoprotein Deficiency
Hypolipidaemia	Lipoprotein Deficiency Disorder
High-Density Lipoid Deficiency	High-Density Lipoprotein Deficiency
Dyslipidaemia, Depressed Hdl Cholesterol

Coronary Heart Disease 1

Coronary Heart Disease	Coronary Heart Disease, Susceptibility To, 1
Chds1	Coronary Heart Disease, Susceptibility To
CHD	Heart, Coronary, Disease, Susceptibility To, Type 1
Coronary Arteriosclerosis	Coronary Artery Disease

Sitosterolemia

Phytosterolemia	Beta-Sitosterolemia
Plant Sterol Storage Disease	Phytosterolæmia
Sitosterolæmia	Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body
Phytosterolaemia	Sitosterolaemia
Sitosterolemia With Xanthomatosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00832	APOA5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APOA5	VGNC	VGNC:107423
Bos taurus	APOA5	VGNC	VGNC:26025
Felis catus	APOA5	VGNC	VGNC:59853
Canis familiaris	APOA5	VGNC	VGNC:37993
Mus musculus	APOA5	MGD	MGI:1913363
Rattus norvegicus	APOA5	RGD	RGD:70903
Others	APOA5	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.