Apoa5 Antibody (YA4338)(PBS only)
(Synonyms: RAP3; APOAV; APOA-V)Apoa5 Antibody (YA4338) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Apoa5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
Apoa5 Antibody (YA4338) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Apoa5.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 42-45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Purified recombinant fragment of human APOA5 (AA: 20-363) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Apoa5 is a Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin[1].
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Subcellular Localization
Secreted; Early endosome; Late endosome; Golgi apparatus, trans-Golgi network
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Expression
Tissue_specificity:liver and plasma
Induction:Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates) -
Subunit
Interacts with GPIHBP1 (PubMed:17997385). Interacts with SORL1; this interaction leads to APOA5 internalization and sorting either to lysosomes and degradation, or to the trans-Golgi network (PubMed:17326667, PubMed:18603531)
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SwissProt ID
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Synonyms
RAP3; APOAV; APOA-V
Documentation
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