CMTM6 - CKLF like MARVEL transmembrane domain containing 6 Gene

Also Known as CKLFSF6; PRO2219

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54918

About CMTM6

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,481,312-32,502,852 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 47.3), thyroid (RPKM 44.1) and 25 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM6 Products (1)

mRNA Protein Name
NM_017801.3 NP_060271.1 CKLF-like MARVEL transmembrane domain-containing protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28813410 GOA
Biological Process GO Annotation Evidence References Source
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
28813417 GOA
involved in protein transport IMP
IMP: Inferred from mutant phenotype
28813417 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
28813410 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
28813417 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28813410 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
28813417 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM6 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (39 - 153)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

CKLF-like MARVEL transmembrane domain-containing protein 6

  • chemokine-like factor super family 6

CMTM6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CMTM6 Q9NX76 CD274 Homo sapiens Q9NZQ7
Anti Bait CoIP
28813410
Intra
CMTM6 Q9NX76 CD274 Homo sapiens Q9NZQ7
Confocal
28813417
Intra
CMTM6 Q9NX76 CD274 Homo sapiens Q9NZQ7
Anti Bait CoIP
28813417
Intra
CMTM6 Q9NX76 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
CMTM6 Q9NX76 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
CMTM6 Q9NX76 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
CMTM6 Q9NX76 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02868 CMTM6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20889 Cmtm6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27406 Cmtm6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CMTM6 MGD MGI:2447165
Macaca mulatta CMTM6 VGNC VGNC:84199
Rattus norvegicus CMTM6 RGD RGD:1307765
Canis familiaris CMTM6 VGNC VGNC:39383
Bos taurus CMTM6 VGNC VGNC:27486
Felis catus CMTM6 VGNC VGNC:102677
Others CMTM6 NCBI