TMEM97 - transmembrane protein 97 Gene

Also Known as MAC30; sigma2R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27346

About TMEM97

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,319,200-28,328,685 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Broad expression in testis (RPKM 51.1), liver (RPKM 43.9) and 23 other tissues.

Summary

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular Cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM97 Products (1)

mRNA	Protein	Name
NM_014573.3	NP_055388.2	sigma intracellular receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19583955	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	19583955	GOA
involved in positive regulation of lipoprotein transport	IMP IMP: Inferred from mutant phenotype	30443021	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	34233061	GOA
involved in regulation of intracellular cholesterol transport	IMP IMP: Inferred from mutant phenotype	27378690	GOA
involved in regulation of intracellular lipid transport	IMP IMP: Inferred from mutant phenotype	27378690	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34233061	GOA
located in lysosome	IDA IDA: Inferred from direct assay	19583955	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	19583955	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19583955	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	19583955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM97 Protein Structure

DUF2781

0
100
176 a.a.

Protein Preferred Names	Protein Names
sigma intracellular receptor 2	meningioma-associated protein 30 sigma-2 receptor sigma2 receptor

TMEM97 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM97	Q5BJF2	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	CLSTN3	Homo sapiens	Q9BQT9	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	CLSTN3	Homo sapiens	Q9BQT9	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CLSTN3	Homo sapiens	Q9BQT9	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	RNF170	Homo sapiens	Q96K19-5	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ASZ1	Homo sapiens	Q8WWH4	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	ASZ1	Homo sapiens	Q8WWH4	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ASZ1	Homo sapiens	Q8WWH4	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	PDCD1LG2	Homo sapiens	Q9BQ51	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	REEP1	Homo sapiens	Q9H902	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	AQP12B	Homo sapiens	A6NM10-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	AQP12B	Homo sapiens	A6NM10-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SLC14A1	Homo sapiens	Q13336-2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	SLC14A1	Homo sapiens	Q13336-2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ATP6AP2	Homo sapiens	O75787	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ATP6AP2	Homo sapiens	O75787	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	NDUFAF2	Homo sapiens	Q8N183	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	NDUFAF2	Homo sapiens	Q8N183	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	NDUFAF2	Homo sapiens	Q8N183	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	LRRC59	Homo sapiens	Q96AG4	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GJB3	Homo sapiens	O75712	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	GJB3	Homo sapiens	O75712	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	FRMD3	Homo sapiens	A2A2Y4	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	FRMD3	Homo sapiens	A2A2Y4	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	NDUFAF1	Homo sapiens	Q9Y375	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	NDUFAF1	Homo sapiens	Q9Y375	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	NDUFAF1	Homo sapiens	Q9Y375	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TMEM97	Q5BJF2	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183
Intra	TMEM97	Q5BJF2	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	32296183
Intra	TMEM97	Q5BJF2	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C
Combined Oxidative Phosphorylation Deficiency 37	COXPD37

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117731	UKH-1114	Agonist	99.88%	Unkown
HY-RS14750	TMEM97 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14751	Tmem97 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14752	Tmem97 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM97	RGD	RGD:1307423
Mus musculus	TMEM97	MGD	MGI:1916321
Macaca mulatta	TMEM97	VGNC	VGNC:79683
Bos taurus	TMEM97	VGNC	VGNC:36129
Canis familiaris	TMEM97	VGNC	VGNC:47617
Felis catus	TMEM97	VGNC	VGNC:97664
Others	TMEM97	NCBI