AQP2 - aquaporin 2 Gene

Also Known as NDI2; AQP-CD; WCH-CD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 359

About AQP2

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,950,737-49,958,878 (from NCBI)

This gene has 3 transcripts (splice variants), 168 orthologues, 11 paralogues and is associated with 2 phenotypes. Restricted expression toward kidney (RPKM 245.3).

Summary

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/Aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

AQP2 Products (1)

mRNA	Protein	Name
NM_000486.6	NP_000477.1	aquaporin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycerol transmembrane transporter activity	IDA IDA: Inferred from direct assay	8584435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA
enables water channel activity	EXP EXP: Inferred from Experiment	9829975	GOA
enables water channel activity	IMP IMP: Inferred from mutant phenotype	8140421	GOA
enables water transmembrane transporter activity	IDA IDA: Inferred from direct assay	8584435	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	32176498	GOA
involved in cellular response to copper ion	IDA IDA: Inferred from direct assay	8584435	GOA
involved in cellular response to mercury ion	IDA IDA: Inferred from direct assay	8584435	GOA
involved in glycerol transmembrane transport	IDA IDA: Inferred from direct assay	8584435	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	24733887	GOA
involved in renal water homeostasis	IMP IMP: Inferred from mutant phenotype	8140421	GOA
involved in water transport	IDA IDA: Inferred from direct assay	8584435	GOA
involved in water transport	IMP IMP: Inferred from mutant phenotype	8140421	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15509592	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in membrane	IDA IDA: Inferred from direct assay	22375059	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9321919	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8140421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP2 Protein Structure

MIP

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
aquaporin-2	ADH water channel

AQP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AQP2	P41181	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	AQP2	P41181	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	32296183
Intra	AQP2	P41181	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	AQP2	P41181	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	AQP2	P41181	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	AQP2	P41181	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	AQP2	P41181	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	AQP2	P41181	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	AQP2	P41181	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	AQP2	P41181	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	AQP2	P41181	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	AQP2	P41181	SLC26A6	Homo sapiens	Q9BXS9-3	Validated Y2H	32296183
Intra	AQP2	P41181	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Array	32296183
Intra	AQP2	P41181	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	OR10AG1	Homo sapiens	Q8NH19	Validated Y2H	32296183
Intra	AQP2	P41181	TMEM236	Homo sapiens	Q5W0B7	Validated Y2H	32296183
Intra	AQP2	P41181	PPGB	Homo sapiens	Q59EV6	Validated Y2H	32296183
Intra	AQP2	P41181	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	AQP2	P41181	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	AQP2	P41181	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	AQP2	P41181	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	AQP2	P41181	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	AQP2	P41181	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	AQP2	P41181	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	AQP2	P41181	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	AQP2	P41181	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	AQP2	P41181	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	AQP2	P41181	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	AQP2	P41181	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	AQP2	P41181	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	AQP2	P41181	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	AQP2	P41181	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	AQP2	P41181	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	AQP2	P41181	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	AQP2	P41181	PANX1	Homo sapiens	Q96RD7	Validated Y2H	32296183
Intra	AQP2	P41181	PANX1	Homo sapiens	Q96RD7	Y2H Array	32296183
Intra	AQP2	P41181	PANX1	Homo sapiens	Q96RD7	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	AQP2	P41181	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	AQP2	P41181	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	AQP2	P41181	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	AQP2	P41181	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	AQP2	P41181	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	AQP2	P41181	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	AQP2	P41181	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	AQP2	P41181	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	AQP2	P41181	PNLIPRP1	Homo sapiens	P54315	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

AQP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82397	Aquaporin 2 Antibody (YA2142)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82397A	Aquaporin 2 Antibody (YA2142)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P84302	Aquaporin 2 Antibody (YA3999)	WB, ELISA	Human
HY-P84302A	Aquaporin 2 Antibody (YA3999)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Diabetes Insipidus, Nephrogenic, 2, Autosomal	Diabetes Insipidus, Nephrogenic, Autosomal NDI2 Diabetes Insipidus, Nephrogenic, Type Ii Diabetes Insipidus, Nephrogenic, 2 Nephrogenic Diabetes Insipidus Type 2 Autosomal Nephrogenic Diabetes Insipidus-2 Diabetes Insipidus, Nephrogenic Type 2 ANDI Diabetes Insipidus Nephrogenic Type 2 Doid:0081061 Nephrogenic Diabetes Insipidus Congenital Nephrogenic Diabetes Insipidus Adh-Resistant Diabetes Insipidus
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Diabetes Insipidus
Central Diabetes Insipidus	Neurogenic Diabetes Insipidus Diabetes Insipidus Cranial Type Diabetes Insipidus Neurogenic Diabetes Insipidus Neurohypophyseal Neurohypophyseal Diabetes Insipidus Pituitary Diabetes Insipidus Cdi Doid:0081055 Diabetes Insipidus Di - [Diabetes Insipidus] Adh - [Antidiuretic Hormone Secretion] Deficiency Diabetes Mellitus Insipidus Familial Diabetes Insipidus Antidiuretic Hormone Hyposecretion Vasopressin Deficiency Syndrome Primary Central Diabetes Insipidus Vasopressin Deficiency Vasopressin Hyposecretion Diabetes Insipidus Secondary To Vasopressin Deficiency
Inappropriate Adh Syndrome	Syndrome Of Inappropriate Antidiuretic Hormone Secretion Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone Siadh Syndrome Of Inappropriate Vasopressin Secretion Syndrome Of Inappropriate Secretion Of Adh Inappropriate Secretion Of Antidiuretic Hormone Syndrome Of Inappropriate Antidiuresis Siadh - [Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone] Antidiuretic Hormone Syndrome Hormone Secretion Inadequate Antidiuretic Hormone Secretion Syndrome Schwartz-Bartter Syndrome Siad - [Syndrome Of Inappropriate Antidiuresis] Hypersecretion Of Antidiuretic Hormone
Ureteral Obstruction
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Hereditary Nephrogenic Diabetes Insipidus
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
X-Linked Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus Type 1 Doid:0081060
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Hepatorenal Syndrome	Hepato-Renal Syndrome Hepatorenal Failure Hrf - [Hepatorenal Failure] Hepatorenal Degeneration Hepatic Renal Syndrome Hepatic Renal Failure Renal Hepatic Failure Urohepatic Syndrome
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Metabolic Acidosis
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Central Pontine Myelinolysis	Myelinolysis, Central Pontine Osmotic Demyelination Syndrome Cpm Myelinolysis Central Pontine Central Pontine Myelinosis
Dipsogenic Diabetes Insipidus	Primary Polydipsia Doid:0081058 Psychogenic Polydipsia
Bartter Syndrome, Type 5, Antenatal, Transient	Bartter Disease Type 5 BARTS5 Bartter Syndrome Type 5 Bartter Syndrome Type V Transient Antenatal Bartter Syndrome Bartter Syndrome 5, Antenatal, Transient
Diabetes Insipidus, Neurohypophyseal	Neurohypophyseal Diabetes Insipidus Cdi Pituitary Diabetes Insipidus Vasopressin Defective Diabetes Insipidus Vasopressin Deficiency Central Diabetes Insipidus Diabetes Insipidus, Neurogenic Diabetes Insipidus, Primary Central Diabetes Insipidus, Cranial Type Diabetes Insipidus Secondary To Vasopressin Deficiency Diabetes Insipidus, Central Diabetes Insipidus, Pituitary NDI Diabetes Insipidus Cranial Type Neurogenic Diabetes Insipidus Primary Central Diabetes Insipidus
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Peripheral Vertigo	Vertigo, Peripheral
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Gestational Diabetes Insipidus	Transient Diabetes Insipidus Of Pregnancy Diabetes Insipidus Gestational Gestagenic Diabetes Insipidus Doid:0081057
Pyelonephritis
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Bartter Disease	Bartter Syndrome Bartter'S Syndrome Aldosteronism With Hyperplasia Of The Adrenal Cortex Hypokalemic Alkalosis With Hypercalciuria Potassium Wasting Juxtaglomerular Hyperplasia With Secondary Aldosteronism Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria Salt-Losing Tubular Disorder, Henle'S Loop Type Salt-Wasting Tubulopathy, Henle'S Loop Type Bartters Syndrome
Meniere Disease	Meniere'S Disease Otogenic Vertigo Ménière Disease Ménière'S Disease Mnire'S Vertigo Auditory Vertigo Aural Vertigo Meniere'S Syndrome Ménière'S Vertigo Primary Endolymphatic Hydrops Menieres Disease Vertigo, Aural Labyrinth Hydrops Labyrinthine Hydrops Labyrinthine Vertigo Ménière Syndrome Ménière Vertigo Idiopathic Endolymphatic Hydrops
Vestibular Disease	Vestibular Diseases Vertigo, Vestibular Disorder Vestibular Disorder Diseases Of Inner Ear
Kidney Papillary Necrosis	Necrotizing Renal Papillitis Papillary Necrosis Renal Papillitis Necrotizing
Renal Glucosuria	Renal Glycosuria Familial Renal Glucosuria GLYS Glys1 Glycosuria, Renal Glucosuria, Renal Renal Diabetes Familial Renal Glycosuria Sglt2 Deficiency Gly Diabetes Renal
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Bartter Syndrome, Type 1, Antenatal	Hyperprostaglandin E Syndrome 1 Bartter Disease Type 1 BARTS1 Bartter Syndrome, Type 1 Bartter Syndrome Type 1 Hypokalemic Alkalosis With Hypercalciuria Antenatal 1 Hypokalemic Alkalosis With Hypercalciuria 1, Antenatal Bartter Syndrome Type 1 Antenatal Hypokalemic Alkalosis With Hypercalciuria 1 Antenatal Bartter Syndrome Antenatal Type 1 Antenatal Bartter Syndrome Type 1 Bartter Syndrome Type I Bartter Syndrome 1, Antenatal Abs1 Antenatal Bartter Syndrome 1 Bs1 Bartter Syndrome, Antenatal Type 1 Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Renal Tubular Acidosis	Acidosis Renal Tubular Acidosis, Renal Tubular Lightwood-Albright Syndrome Lightwood Syndrome Idiopathic Infantile Hypercalcemia - Mild Form Kidney Tubular Acidosis Renal Tubule Acidosis Kidney Acidosis Renal Acidosis Renal Hyperchloremic Acidosis Rta - [Renal Tubular Acidosis]
Gitelman Syndrome	Familial Hypokalemia-Hypomagnesemia Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria Potassium And Magnesium Depletion GTLMNS Gitelman'S Syndrome Gs Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria Bartter Syndrome Gitelman Variant Bartter Syndrome Hypocalciuric Variant Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Congenital Anomalies Of Kidney And Urinary Tract 2	CAKUT2 Ureteropelvic Junction Obstruction Multicystic Renal Dysplasia, Bilateral Pelviureteric Junction Obstruction Pujo Hydronephrosis Due To Pujo Upjo Mcrd Congenital Anomalies Of The Kidney And Urinary Tract 2 Mrd Pelvi-Ureteric Junction Obstruction Kidney And Urinary Tract, Anomalies, Congenital, Type 2 Obstruction Of Pelviureteric Junction
Obstructive Nephropathy	Con Congenital Obstructive Nephropathy Nephropathy Obstructive
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism Liddle'S Syndrome LIDLS1 Lidls Pseudohyperaldosteronism Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2057	Steviol	Inhibitor	99.85%	Unkown
HY-W288951	FMP-API-1	Activator	95.51%	Unkown
HY-E70797	Biotin-CaMK2δ CAMK2D Recombinant Human Active Protein Kinase		/	Unkown
HY-RS00874	AQP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17446	Aqp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18336	Aqp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24815	Aqp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AQP2	VGNC	VGNC:26046
Felis catus	AQP2	VGNC	VGNC:83495
Mus musculus	AQP2	MGD	MGI:1096865
Macaca mulatta	AQP2	VGNC	VGNC:99888
Canis familiaris	AQP2	VGNC	VGNC:38017
Rattus norvegicus	AQP2	RGD	RGD:2142
Others	AQP2	NCBI