Aquaporin 2 Antibody (YA3999)
(Synonyms: AQP-CD; WCH-CD)Aquaporin 2 Antibody (YA3999) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aquaporin 2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:10000 |
Product Details
Aquaporin 2 Antibody (YA3999) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aquaporin 2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 40-50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 29 kDa
Purified recombinant fragment of human AQP2 (AA: 149-271) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Aquaporin 2 forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Could also be permeable to glycerol[1][2][3][4][5].
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Subcellular Localization
Apical cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein; Cytoplasmic vesicle membrane; Multi-pass membrane protein; Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:It is expressed (protein level) in the renal medullary collecting ducts (PubMed: 7510718) . It was detected in the kidneys (PubMed: 7510718) . -
Subunit
Homotetramer (PubMed:24733887). Interacts with micropeptide MIAC; the interaction leads to a reduction of filamentous actin fibers and inhibition of the EREG/EGFR signaling pathway (PubMed:32176498, PubMed:36117171)
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SwissProt ID
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Synonyms
AQP-CD; WCH-CD
Documentation
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