TMEM109 - transmembrane protein 109 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79073

About TMEM109

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,914,158-60,923,443 (from NCBI)

This gene has 3 transcripts (splice variants) and 118 orthologues. Ubiquitous expression in fat (RPKM 44.7), lung (RPKM 42.9) and 25 other tissues.

Summary

Predicted to enable voltage-gated ion channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

TMEM109 Products (1)

mRNA Protein Name
NM_024092.3 NP_076997.1 transmembrane protein 109 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
23542032 GOA
acts upstream of or within negative regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
23542032 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM109 Protein Structure

BRI3BP

BRI3BP: Negative regulator of p53/TP53 (54 - 232)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

transmembrane protein 109

  • mg23

TMEM109 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM109 Q9BVC6 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 SPINT1 Homo sapiens O43278-2
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 SPINT1 Homo sapiens O43278-2
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 AQP9 Homo sapiens O43315
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 AQP9 Homo sapiens O43315
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 SLC18A2 Homo sapiens Q05940
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 SLC18A2 Homo sapiens Q05940
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
TMEM109 Q9BVC6 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
TMEM109 Q9BVC6 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
TMEM109 Q9BVC6 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
TMEM109 Q9BVC6 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TMEM109 Q9BVC6 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14650 TMEM109 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMEM109 VGNC VGNC:66259
Macaca mulatta TMEM109 VGNC VGNC:79740
Canis familiaris TMEM109 VGNC VGNC:47450
Rattus norvegicus TMEM109 RGD RGD:1359538
Mus musculus TMEM109 MGD MGI:1915789
Bos taurus TMEM109 VGNC VGNC:35949
Others TMEM109 NCBI