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MGST3 - microsomal glutathione S-transferase 3 Gene

Also Known as GST-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4259

About MGST3

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,631,234-165,656,136 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues.

Summary

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

MGST3 Products (1)

mRNA	Protein	Name
NM_004528.4	NP_004519.1	microsomal glutathione S-transferase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glutathione peroxidase activity	IDA IDA: Inferred from direct assay	9278457	GOA
NOT enables glutathione transferase activity	IDA IDA: Inferred from direct assay	9278457	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	36370807	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables leukotriene-C4 synthase activity	IDA IDA: Inferred from direct assay	9278457	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	9278457	GOA
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	9278457	GOA
involved in prostanoid metabolic process	IDA IDA: Inferred from direct assay	36370807	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	9278457	GOA
located in membrane	IDA IDA: Inferred from direct assay	9278457	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	27184847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGST3 Protein Structure

MAPEG

0
100
152 a.a.

Protein Preferred Names	Protein Names
microsomal glutathione S-transferase 3	LTC4 synthase MGST3

MGST3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MGST3	O14880	GRM2	Homo sapiens	Q14416	Validated Y2H	32296183
Intra	MGST3	O14880	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	MGST3	O14880	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	32296183
Intra	MGST3	O14880	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	MGST3	O14880	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	MGST3	O14880	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	MGST3	O14880	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	TFAM	Homo sapiens	Q00059	Validated Y2H	32296183
Intra	MGST3	O14880	TFAM	Homo sapiens	Q00059	Y2H Array	32296183
Intra	MGST3	O14880	TFAM	Homo sapiens	Q00059	BioID	29568061
Intra	MGST3	O14880	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	MGST3	O14880	SEC22B	Homo sapiens	O75396	Validated Y2H	32296183
Intra	MGST3	O14880	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	MGST3	O14880	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	MGST3	O14880	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	MGST3	O14880	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	MGST3	O14880	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	SNORC	Homo sapiens	Q6UX34	Validated Y2H	32296183
Intra	MGST3	O14880	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	MGST3	O14880	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	MGST3	O14880	TSPAN33	Homo sapiens	Q86UF1	Validated Y2H	32296183
Intra	MGST3	O14880	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	MGST3	O14880	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	MGST3	O14880	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	MGST3	O14880	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	MGST3	O14880	LEMD1	Homo sapiens	Q68G75	Validated Y2H	32296183
Intra	MGST3	O14880	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	MGST3	O14880	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	MGST3	O14880	SLC35A1	Homo sapiens	P78382	Validated Y2H	32296183
Intra	MGST3	O14880	SYS1	Homo sapiens	Q8N2H4	Validated Y2H	32296183
Intra	MGST3	O14880	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	MGST3	O14880	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	MGST3	O14880	STX3	Homo sapiens	Q13277	Validated Y2H	32296183
Intra	MGST3	O14880	PPGB	Homo sapiens	Q59EV6	Validated Y2H	32296183
Intra	MGST3	O14880	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	MGST3	O14880	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	MGST3	O14880	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	CLRN1	Homo sapiens	P58418	Validated Y2H	32296183
Intra	MGST3	O14880	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	MGST3	O14880	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	MGST3	O14880	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	TSPAN12	Homo sapiens	O95859	Validated Y2H	32296183
Intra	MGST3	O14880	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	MGST3	O14880	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	MGST3	O14880	PAGE1	Homo sapiens	O75459	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	PAGE1	Homo sapiens	O75459	Validated Y2H	32296183
Intra	MGST3	O14880	PAGE1	Homo sapiens	O75459	Y2H Array	32296183
Intra	MGST3	O14880	ITGAM	Homo sapiens	P11215	Validated Y2H	32296183
Intra	MGST3	O14880	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	MGST3	O14880	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
Intra	MGST3	O14880	ARL6IP6	Homo sapiens	Q8N6S5	Validated Y2H	32296183
Intra	MGST3	O14880	AQP3	Homo sapiens	Q92482	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	MGST3	O14880	AQP3	Homo sapiens	Q92482	Y2H Array	32296183
Intra	MGST3	O14880	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	MGST3	O14880	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	MGST3	O14880	SLC39A9	Homo sapiens	Q9NUM3	Y2H Array	32296183
Intra	MGST3	O14880	SLC39A9	Homo sapiens	Q9NUM3	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	SLC2A5	Homo sapiens	P22732	Validated Y2H	32296183
Intra	MGST3	O14880	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	MGST3	O14880	C11orf24	Homo sapiens	Q96F05	Validated Y2H	32296183
Intra	MGST3	O14880	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	MGST3	O14880	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	MGST3	O14880	STX7	Homo sapiens	O15400	Validated Y2H	32296183
Intra	MGST3	O14880	TFRC	Homo sapiens	P02786	Validated Y2H	32296183
Intra	MGST3	O14880	SLC1A3	Homo sapiens	P43003	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	SLC1A3	Homo sapiens	P43003	Validated Y2H	32296183
Intra	MGST3	O14880	SLC1A3	Homo sapiens	P43003	Y2H Array	32296183
Intra	MGST3	O14880	TSPAN2	Homo sapiens	O60636	Validated Y2H	32296183
Intra	MGST3	O14880	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	MGST3	O14880	BMP10	Homo sapiens	O95393	Validated Y2H	32296183
Intra	MGST3	O14880	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	MGST3	O14880	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	MGST3	O14880	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
Intra	MGST3	O14880	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	MGST3	O14880	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	MGST3	O14880	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	MGST3	O14880	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	MGST3	O14880	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	MGST3	O14880	GIMAP5	Homo sapiens	Q96F15	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
Intra	MGST3	O14880	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	MGST3	O14880	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	MGST3	O14880	PLN	Homo sapiens	P26678	Validated Y2H	32296183
Intra	MGST3	O14880	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	MGST3	O14880	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	MGST3	O14880	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	MGST3	O14880	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	MGST3	O14880	HMOX2	Homo sapiens	P30519	Validated Y2H	32296183
Intra	MGST3	O14880	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	MGST3	O14880	FUNDC2	Homo sapiens	Q9BWH2	Validated Y2H	32296183
Intra	MGST3	O14880	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	32296183
Intra	MGST3	O14880	APOD	Homo sapiens	P05090	Validated Y2H	32296183
Intra	MGST3	O14880	ZFPL1	Homo sapiens	O95159	Validated Y2H	32296183
Intra	MGST3	O14880	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	MGST3	O14880	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	MGST3	O14880	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	33961781
Intra	MGST3	O14880	BIRC6	Homo sapiens	Q9NR09	BioID	29568061
Intra	MGST3	O14880	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	28514442
Intra	MGST3	O14880	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	MGST3	O14880	VAMP4	Homo sapiens	O75379	Validated Y2H	32296183
Intra	MGST3	O14880	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	MGST3	O14880	BET1	Homo sapiens	O15155	Validated Y2H	32296183
Intra	MGST3	O14880	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	MGST3	O14880	MIP	Homo sapiens	P30301	Validated Y2H	32296183
Intra	MGST3	O14880	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	MGST3	O14880	CACNG1	Homo sapiens	Q06432	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MGST3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83478	MGST3 Antibody (YA3223)	WB, IHC-P, IP	Human
HY-P83478A	MGST3 Antibody (YA3223)(PBS only)	WB, IHC-P, IP	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08418	MGST3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21646	Mgst3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28164	Mgst3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MGST3	VGNC	VGNC:68253
Bos taurus	MGST3	VGNC	VGNC:31453
Mus musculus	MGST3	MGD	MGI:1913697
Macaca mulatta	MGST3	VGNC	VGNC:74720
Canis familiaris	MGST3	VGNC	VGNC:53121
Rattus norvegicus	MGST3	RGD	RGD:1306373
Others	MGST3	NCBI