VAMP4 - vesicle associated membrane protein 4 Gene

Also Known as VAMP-4; VAMP24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8674

About VAMP4

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,700,160-171,742,065 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 10 paralogues. Ubiquitous expression in brain (RPKM 9.9), testis (RPKM 7.1) and 25 other tissues.

Summary

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

VAMP4 Products (2)

mRNA Protein Name
NM_001185127.2 NP_001172056.1 vesicle-associated membrane protein 4 isoform 2
NM_003762.5 NP_003753.2 vesicle-associated membrane protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IDA
IDA: Inferred from direct assay
21151919 GOA
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
23677696 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23677696 GOA
located in cell surface IDA
IDA: Inferred from direct assay
21151919 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP4 Protein Structure

Synaptobrevin

Synaptobrevin: Synaptobrevin (50 - 136)

  • 0
  • 100
  • 141 a.a.
Protein Preferred Names Protein Names

vesicle-associated membrane protein 4

  • VAMP4/TAF3 fusion

VAMP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
32296183
Intra
VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
26359495
Intra
VAMP4 O75379 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
33961781
Intra
VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
VAMP4 O75379 CYB5R3 Homo sapiens P00387
Validated Y2H
32296183
Intra
VAMP4 O75379 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
VAMP4 O75379 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra
VAMP4 O75379 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
VAMP4 O75379 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
VAMP4 O75379 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
VAMP4 O75379 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
VAMP4 O75379 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
VAMP4 O75379 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
VAMP4 O75379 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
VAMP4 O75379 EVI2B Homo sapiens P34910-2
Validated Y2H
32296183
Intra
VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
25419848
Intra
VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
19557002
Intra
VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
33961781
Intra
VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Intra
VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra
VAMP4 O75379 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
VAMP4 O75379 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Validated Y2H
32296183
Intra
VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra
VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra
VAMP4 O75379 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
VAMP4 O75379 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
VAMP4 O75379 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 STX4 Homo sapiens Q12846
Anti Tag CoIP
33961781
Intra
VAMP4 O75379 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra
VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Array
25416956
Intra
VAMP4 O75379 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra
VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra
VAMP4 O75379 STX16 Homo sapiens O14662-5
Y2H Array
32296183
Intra
VAMP4 O75379 STX16 Homo sapiens O14662-5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Infant Botulism

  • Infant Intestinal Botulism

  • Infant Intestinal Toxemia Botulism

  • Infant Intestinal Toxin-Mediated Botulism

  • Infantile Botulism

  • Botulism, Infantile
Pontocerebellar Hypoplasia, Type 2e

  • Pontocerebellar Hypoplasia Type 2

  • Pontocerebellar Hypoplasia Type 2e

  • Pch2

  • PCH2E

  • Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

  • Pontocerebellar Hypoplasia 2e

  • Pcca2

  • Progressive Cerebello-Cerebral Atrophy Type 2

  • Doid:0112328

  • Hypoplasia, Pontocerebellar, Type 2e

  • Pontocerebellar Hypoplasia, Type 2d

  • Pontocerebellar Hypoplasia Type 2a
Wound Botulism

  • Cutaneous Infectious Botulism

  • Cutaneous Toxin-Mediated Botulism

  • Inoculation Botulism

  • Skin Infectious Botulism

  • Skin Toxin-Mediated Botulism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15596 VAMP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus VAMP4 VGNC VGNC:107961
Bos taurus VAMP4 VGNC VGNC:36758
Rattus norvegicus VAMP4 RGD RGD:1309753
Mus musculus VAMP4 MGD MGI:1858730
Canis familiaris VAMP4 VGNC VGNC:48224
Macaca mulatta VAMP4 VGNC VGNC:78752
Others VAMP4 NCBI