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SLC2A5 - solute carrier family 2 member 5 Gene

Also Known as GLUT5; GLUT-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6518

About SLC2A5

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:9,035,106-9,094,195 (from NCBI)

This gene has 10 transcripts (splice variants), 259 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 33.7), small intestine (RPKM 25.5) and 8 other tissues.

Summary

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]

SLC2A5 Products (5)

mRNA	Protein	Name
NM_001135585.2	NP_001129057.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 2
NM_001328619.2	NP_001315548.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 1
NM_001328620.2	NP_001315549.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 3
NM_001328621.2	NP_001315550.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 4
NM_003039.3	NP_003030.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	8333543	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fructose import across plasma membrane	IDA IDA: Inferred from direct assay	8333543	GOA
involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	28083649	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8333543	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A5 Protein Structure

Sugar_tr

0
100
200
300
400
501 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 5	glucose transporter type 5, small intestine

SLC2A5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC2A5	P22732	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	SLC2A5	P22732	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC2A5	P22732	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	SLC2A5	P22732	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SLC2A5	P22732	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	SLC2A5	P22732	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	SLC2A5	P22732	FCRL3	Homo sapiens	Q96P31-6	Y2H Array	32296183
Intra	SLC2A5	P22732	FCRL3	Homo sapiens	Q96P31-6	Validated Y2H	32296183
Intra	SLC2A5	P22732	FCRL3	Homo sapiens	Q96P31-6	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	EVI2B	Homo sapiens	P34910-2	Validated Y2H	32296183
Intra	SLC2A5	P22732	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	SLC2A5	P22732	TMEM130	Homo sapiens	Q8N3G9	Validated Y2H	32296183
Intra	SLC2A5	P22732	TMEM130	Homo sapiens	Q8N3G9	Y2H Array	32296183
Intra	SLC2A5	P22732	PAGE1	Homo sapiens	O75459	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	PAGE1	Homo sapiens	O75459	Y2H Array	32296183
Intra	SLC2A5	P22732	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	SLC2A5	P22732	ATP6V0B	Homo sapiens	Q99437	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	SLC2A5	P22732	ATP6V0B	Homo sapiens	Q99437	Y2H Array	32296183
Intra	SLC2A5	P22732	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	SLC2A5	P22732	MTERF3	Homo sapiens	Q96E29	Validated Y2H	32296183
Intra	SLC2A5	P22732	MTERF3	Homo sapiens	Q96E29	Y2H Prey Pooling	32296183
Intra	SLC2A5	P22732	MTERF3	Homo sapiens	Q96E29	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fructosuria, Essential	Essential Fructosuria Ketohexokinase Deficiency Fructosuria Hepatic Fructokinase Deficiency Fructokinase Deficiency FRUCT Deficiency Of Fructokinase
Lactase Deficiency, Congenital	Congenital Lactase Deficiency Disaccharide Intolerance Ii Congenital Alactasia Congenital Alactasia Syndrome Congenital Lactose Intolerance Congenital Lactose Malabsorption Hereditary Alactasia Alactasia, Congenital Cld COLACD Disaccharide Intolerance Type 2 Cld - [Congenital Lactase Deficiency] Disaccharide Intolerance 2 Lactose Intolerance Of Newborn Hereditary Lactase Deficiency
Osmotic Diarrhea
Lung Acinar Adenocarcinoma	Acinar Adenocarcinoma Of The Lung
Fructose Intolerance, Hereditary	Hereditary Fructose Intolerance Fructose Intolerance Fructose-1-Phosphate Aldolase Deficiency Fructose-1,6-Bisphosphate Aldolase B Deficiency Aldolase B Deficiency Fructosemia Aldob Deficiency Hereditary Fructose Intolerance Syndrome HFI Fructosaemia Hereditary Fructose-1-Phosphate Aldolase Deficiency Fructose Aldolase B Deficiency Fructose-1,6-Biphosphate Aldolase Deficiency Hereditary Fructosemia Fructosemia, Hereditary Hereditary Fructosaemia Fructose-Biphosphate Aldolase B Deficiency Fructose Intolerance Of Newborn Aldb - [Aldolase B] Deficiency Deficiency Of Fructose-Bisphosphate Aldolase
Sucrase-Isomaltase Deficiency, Congenital	Congenital Sucrase-Isomaltase Deficiency CSID Si Deficiency Congenital Sucrose Intolerance Disaccharide Intolerance Sucrase-Isomaltase Deficiency Disaccharide Intolerance I Congenital Sucrose-Isomaltose Malabsorption Sucrose-Isomaltose Malabsorption, Congenital Sucrose Intolerance, Congenital Congenital Sucrase-Isomaltose Malabsorption Congenital Sucrose-Isomaltase Malabsorption Disaccharide Intolerance, 1 Sucrose Intolerance Congenital Sucrose-Isomaltase Malabsorption, Congenital Disaccharidase Deficiency Invertase Deficiency Sucrase-Alpha-Dextrinase Deficiency Disaccharide Intolerance Type I Csid - [Congenital Sucrase-Isomaltase Deficiency] Sucrose Intolerance Of Newborn Sucrose Intolerance Sucrase Deficiency Disaccharide Malabsorption Intestinal Disaccharidase Deficiency
Lactose Intolerance	Lactose Malabsorption Lm - Lactose Malabsorption Alactasia Dairy Product Intolerance Hypolactasia Milk Sugar Intolerance Cow Milk Enteropathy Intolerance Or Malabsorption Of Lactose Lm - [Lactose Malabsorption] Milk Intolerance

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13174	SLC2A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC2A5	RGD	RGD:68328
Mus musculus	SLC2A5	MGD	MGI:1928369
Macaca mulatta	SLC2A5	VGNC	VGNC:77450
Others	SLC2A5	NCBI