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NSG1 - neuronal vesicle trafficking associated 1 Gene

Also Known as P21; D4S234; NEEP21; D4S234E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27065

About NSG1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:4,386,532-4,419,058 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in skin (RPKM 37.1), prostate (RPKM 21.2) and 12 other tissues.

Summary

Predicted to enable clathrin light chain binding activity. Involved in apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

NSG1 Products (6)

mRNA	Protein	Name
NM_001040101.2	NP_001035190.1	neuronal vesicle trafficking-associated protein 1 isoform a
NM_001287763.2	NP_001274692.1	neuronal vesicle trafficking-associated protein 1 isoform a
NM_001287764.2	NP_001274693.1	neuronal vesicle trafficking-associated protein 1 isoform b
NM_001382227.1	NP_001369156.1	neuronal vesicle trafficking-associated protein 1 isoform c
NM_001382228.1	NP_001369157.1	neuronal vesicle trafficking-associated protein 1 isoform d
NM_014392.5	NP_055207.1	neuronal vesicle trafficking-associated protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20599942	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20599942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSG1 Protein Structure

Calcyon

0
100
185 a.a.

Protein Preferred Names	Protein Names
neuronal vesicle trafficking-associated protein 1	brain neuron cytoplasmic protein 1

NSG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NSG1	P42857	BSCL2	Homo sapiens	Q96G97-4	Y2H Prey Pooling	25416956
Intra	NSG1	P42857	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	NSG1	P42857	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	NSG1	P42857	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	NSG1	P42857	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	NSG1	P42857	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	NSG1	P42857	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	NSG1	P42857	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	NSG1	P42857	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	NSG1	P42857	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	NSG1	P42857	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FIMP	Homo sapiens	Q96LL3	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FIMP	Homo sapiens	Q96LL3	Y2H Array	32296183
Intra	NSG1	P42857	FIMP	Homo sapiens	Q96LL3	Validated Y2H	32296183
Intra	NSG1	P42857	TMEM207	Homo sapiens	Q6UWW9	Validated Y2H	32296183
Intra	NSG1	P42857	TMEM207	Homo sapiens	Q6UWW9	Y2H Array	32296183
Intra	NSG1	P42857	TMEM207	Homo sapiens	Q6UWW9	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	NSG1	P42857	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	NSG1	P42857	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	NSG1	P42857	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FCGR2A	Homo sapiens	P12318-2	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FCGR2A	Homo sapiens	P12318-2	Y2H Array	32296183
Intra	NSG1	P42857	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	NSG1	P42857	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	NSG1	P42857	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	NSG1	P42857	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	BTN2A1	Homo sapiens	Q7KYR7-4	Validated Y2H	32296183
Intra	NSG1	P42857	BTN2A1	Homo sapiens	Q7KYR7-4	Y2H Array	32296183
Intra	NSG1	P42857	BTN2A1	Homo sapiens	Q7KYR7-4	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	NSG1	P42857	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	NSG1	P42857	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	NSG1	P42857	ATP6AP2	Homo sapiens	O75787	Y2H Array	32296183
Intra	NSG1	P42857	ATP6AP2	Homo sapiens	O75787	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	NSG1	P42857	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	NSG1	P42857	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	NSG1	P42857	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	GPA33	Homo sapiens	Q99795	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	GPA33	Homo sapiens	Q99795	Validated Y2H	32296183
Intra	NSG1	P42857	GPA33	Homo sapiens	Q99795	Y2H Array	32296183
Intra	NSG1	P42857	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	NSG1	P42857	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	NSG1	P42857	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	NSG1	P42857	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	NSG1	P42857	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	NSG1	P42857	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	NSG1	P42857	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	NSG1	P42857	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	NSG1	P42857	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	PLPP2	Homo sapiens	O43688	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	PLPP2	Homo sapiens	O43688	Y2H Array	32296183
Intra	NSG1	P42857	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	NSG1	P42857	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	NSG1	P42857	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	NSG1	P42857	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	NSG1	P42857	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	NSG1	P42857	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	NSG1	P42857	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	NSG1	P42857	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	NSG1	P42857	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	NSG1	P42857	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	NSG1	P42857	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	NSG1	P42857	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spondylocostal Dysostosis 1, Autosomal Recessive	Jarcho-Levin Syndrome SCDO1 Vertebral Anomalies Spondylothoracic Dysplasia Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylocostal Dysostosis 1 Autosomal Recessive Spondylocostal Dysostosis 1 Spondylocostal Dysostosis, Autosomal Recessive, 1 Doid:0112365 Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09593	NSG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NSG1	RGD	RGD:2222
Felis catus	NSG1	VGNC	VGNC:78539
Bos taurus	NSG1	VGNC	VGNC:32276
Macaca mulatta	NSG1	VGNC	VGNC:75433
Canis familiaris	NSG1	VGNC	VGNC:43985
Mus musculus	NSG1	MGD	MGI:109149
Others	NSG1	NCBI