2. Gene
  3. PLPP2 - phospholipid phosphatase 2 Gene

PLPP2 - phospholipid phosphatase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LPP2; PAP-2c; PAP2-g; PPAP2C

Gene ID: 8612 | Gene type: protein coding

About PLPP2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:281,043-291,403 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 9 paralogues. Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is similar to phosphatidic Acid Phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PLPP2 Products(3)

mRNA Protein Name
NM_003712.4 NP_003703.1 phospholipid phosphatase 2 isoform 1
NM_177526.3 NP_803545.1 phospholipid phosphatase 2 isoform 2
NM_177543.3 NP_808211.1 phospholipid phosphatase 2 isoform 3

PLPP2 Protein Structure

PAP2

PAP2: PAP2 superfamily (45 - 187)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 2

PAP2-gamma

Related Diseases

Diseases Alias
Myxosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10735 PLPP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLPP2 RGD RGD:628893
Mus musculus PLPP2 MGD MGI:1354945
Felis catus PLPP2 VGNC VGNC:80656
Canis familiaris PLPP2 VGNC VGNC:44706
Bos taurus PLPP2 VGNC VGNC:33045