PLPP2 - phospholipid phosphatase 2 Gene

Also Known as LPP2; PAP-2c; PAP2-g; PPAP2C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8612

About PLPP2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:281,043-291,403 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 9 paralogues. Broad expression in gall bladder (RPKM 23.7), duodenum (RPKM 23.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is similar to phosphatidic Acid Phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PLPP2 Products (3)

mRNA Protein Name
NM_003712.4 NP_003703.1 phospholipid phosphatase 2 isoform 1
NM_177526.3 NP_803545.1 phospholipid phosphatase 2 isoform 2
NM_177543.3 NP_808211.1 phospholipid phosphatase 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
9705349 GOA
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
9705349 GOA
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
9705349 GOA
involved in sphingosine metabolic process IDA
IDA: Inferred from direct assay
9705349 GOA
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
16467304 GOA
located in early endosome IDA
IDA: Inferred from direct assay
16467304 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16467304 GOA
located in membrane IDA
IDA: Inferred from direct assay
9705349 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16467304 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP2 Protein Structure

PAP2

PAP2: PAP2 superfamily (45 - 187)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 2

  • PAP2-gamma

PLPP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPP2 O43688 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
PLPP2 O43688 TRAM1L1 Homo sapiens Q8N609
Validated Y2H
32296183
Intra
PLPP2 O43688 VSTM1 Homo sapiens Q6UX27-3
Validated Y2H
32296183
Intra
PLPP2 O43688 NSG1 Homo sapiens P42857
Validated Y2H
32296183
Intra
PLPP2 O43688 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
PLPP2 O43688 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myxosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10735 PLPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLPP2 RGD RGD:628893
Mus musculus PLPP2 MGD MGI:1354945
Felis catus PLPP2 VGNC VGNC:80656
Canis familiaris PLPP2 VGNC VGNC:44706
Bos taurus PLPP2 VGNC VGNC:33045
Others PLPP2 NCBI