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AQP10 - aquaporin 10 Gene

Also Known as AQPA_HUMAN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89872

About AQP10

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,321,093-154,325,325 (from NCBI)

This gene has 3 transcripts (splice variants), 390 orthologues and 11 paralogues. Biased expression in duodenum (RPKM 31.0) and small intestine (RPKM 22.0).

Summary

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

AQP10 Products (1)

mRNA	Protein	Name
NM_080429.3	NP_536354.2	aquaporin-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables glycerol channel activity	IDA IDA: Inferred from direct assay	30420639	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	30420639	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	30420639	GOA
involved in glycerol transmembrane transport	IDA IDA: Inferred from direct assay	30420639	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	30420639	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17575980	GOA
involved in water transport	IDA IDA: Inferred from direct assay	30420639	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	30420639	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP10 Protein Structure

MIP

0
100
200
301 a.a.

Protein Preferred Names	Protein Names
aquaporin-10	AQP-10

AQP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	AQP10	Q96PS8	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	AQP10	Q96PS8	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	AQP10	Q96PS8	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	AQP10	Q96PS8	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	AQP10	Q96PS8	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	AQP10	Q96PS8	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	AQP10	Q96PS8	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	AQP10	Q96PS8	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	AQP10	Q96PS8	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	AQP10	Q96PS8	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	AQP10	Q96PS8	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	AQP10	Q96PS8	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	AQP10	Q96PS8	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	AQP10	Q96PS8	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	AQP10	Q96PS8	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	AQP10	Q96PS8	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	AQP10	Q96PS8	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	AQP10	Q96PS8	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	AQP10	Q96PS8	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	AQP10	Q96PS8	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	AQP10	Q96PS8	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	AQP10	Q96PS8	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
Intra	AQP10	Q96PS8	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	AQP10	Q96PS8	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pompholyx	Dyshidrosis Vesicular Eczema Of Hands And/Or Feet Cheiropompholyx Dyshydrotic Eczema Eczema, Dyshidrotic Vesicular Hand Eczema
Viral Gastritis
Fox-Fordyce Disease	Fox Fordyce Disease Apocrine Miliaria Fox-Fordyce Syndrome Miliaria, Apocrine
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00872	AQP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AQP10	VGNC	VGNC:26044
Macaca mulatta	AQP10	VGNC	VGNC:69841
Rattus norvegicus	AQP10	RGD	RGD:1596307
Felis catus	AQP10	VGNC	VGNC:59859
Others	AQP10	NCBI