PLPP4 - phospholipid phosphatase 4 Gene

Also Known as DPPL2; PPAPDC1; PPAPDC1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196051

About PLPP4

This gene has 3 transcripts (splice variants), 217 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Enables diacylglycerol diphosphate Phosphatase activity; identical protein binding activity; and phosphatidate Phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

PLPP4 Products (5)

mRNA Protein Name
NM_001030059.3 NP_001025230.1 phospholipid phosphatase 4 isoform a
NM_001318166.2 NP_001305095.1 phospholipid phosphatase 4 isoform b
NM_001318167.2 NP_001305096.1 phospholipid phosphatase 4 isoform c
NM_001318168.2 NP_001305097.1 phospholipid phosphatase 4 isoform d
NM_001318169.2 NP_001305098.1 phospholipid phosphatase 4 isoform e

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables phosphatidate phosphatase activity EXP
EXP: Inferred from Experiment
17590538 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
17590538 GOA
involved in regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
28851360 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP4 Protein Structure

PAP2

PAP2: PAP2 superfamily (84 - 226)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 4

  • diacylglycerol pyrophosphate like 2

PLPP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPP4 Q5VZY2 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 PLPP4 Homo sapiens Q5VZY2
Y2H Array
25416956
Intra
PLPP4 Q5VZY2 PLPP4 Homo sapiens Q5VZY2
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 PLPP4 Homo sapiens Q5VZY2
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 PLPP4 Homo sapiens Q5VZY2
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 GJA1 Homo sapiens P17302
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 GJA1 Homo sapiens P17302
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 ANKRD46 Homo sapiens Q86W74-2
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 PAGE1 Homo sapiens O75459
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 PAGE1 Homo sapiens O75459
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 EVI2A Homo sapiens P22794
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 EVI2A Homo sapiens P22794
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 LRRC59 Homo sapiens Q96AG4
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 LRRC59 Homo sapiens Q96AG4
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 LRRC59 Homo sapiens Q96AG4
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 FRMD3 Homo sapiens A2A2Y4
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 FRMD3 Homo sapiens A2A2Y4
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
PLPP4 Q5VZY2 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
PLPP4 Q5VZY2 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra
PLPP4 Q5VZY2 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10737 PLPP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLPP4 MGD MGI:2685936
Bos taurus PLPP4 VGNC VGNC:33047
Canis familiaris PLPP4 VGNC VGNC:49792
Macaca mulatta PLPP4 VGNC VGNC:76097
Rattus norvegicus PLPP4 RGD RGD:1306289
Others PLPP4 NCBI