FUNDC2 - FUN14 domain containing 2 Gene

Also Known as DC44; HCC3; HCBP6; PD03104

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65991

About FUNDC2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,026,844-155,060,304 (from NCBI)

This gene has 7 transcripts (splice variants), 167 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 26.0), ovary (RPKM 19.3) and 25 other tissues.

Summary

Predicted to be involved in Autophagy of mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FUNDC2 Products (1)

mRNA Protein Name
NM_023934.4 NP_076423.2 FUN14 domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
29786068 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
25855506 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUNDC2 Protein Structure

FUN14

FUN14: FUN14 family (86 - 188)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

FUN14 domain-containing protein 2

  • HCC-3

FUNDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FUNDC2 Q9BWH2 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 FGF14 Homo sapiens Q92915-2
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 FGF14 Homo sapiens Q92915-2
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SLC16A10 Homo sapiens Q8TF71
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 SLC16A10 Homo sapiens Q8TF71
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 COX20 Homo sapiens Q5RI15
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SLC66A2 Homo sapiens Q8N2U9
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SLC66A2 Homo sapiens Q8N2U9
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SDR16C5 Homo sapiens Q8N3Y7
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 SDR16C5 Homo sapiens Q8N3Y7
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
FUNDC2 Q9BWH2 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
FUNDC2 Q9BWH2 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
FUNDC2 Q9BWH2 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
FUNDC2 Q9BWH2 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
FUNDC2 Q9BWH2 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Factor Viii Deficiency

  • Autosomal Hemophilia A

  • Hemophilia A

  • Autosomal Factor Viii Deficiency

  • Classic Hemophilia A

  • Congenital Factor Viii Disorder

  • Subhemophilia

  • Factor 8 Deficiency, Congenital

  • Factor Viii
Hemophilia A

  • Factor Viii Deficiency

  • Haemophilia A

  • Mild Hemophilia A

  • HEMA

  • Hemophilia, Classic

  • Classic Hemophilia

  • Factor 8 Deficiency

  • Severe Hemophilia A

  • Classical Hemophilia

  • Hem A

  • Hemophilia A, Congenital

  • Mild Congenital F8 Deficiency

  • Mild Congenital Factor Viii Deficiency

  • Severe Congenital F8 Deficiency

  • Severe Congenital Factor Viii Deficiency

  • Moderate Hemophilia A

  • Moderate Congenital F8 Deficiency

  • Moderate Congenital Factor Viii Deficiency

  • Bleeding Disorder In Hemophilia A Carriers

  • Congenital F8 Deficiency

  • Congenital Fviii Deficiency

  • Congenital Factor Viii Deficiency

  • Mild Hereditary Factor Viii Deficiency Disease

  • Severe Hereditary Factor Viii Deficiency Disease

  • Ahg - [Antihaemophilic Globulin] Deficiency

  • Ahg - [Antihaemophilic Globulin] Deficiency Disease

  • Congenital Factor Viii Disorder

  • Sex-Linked Factor Viii Deficiency

  • Antihaemophilic Globulin Deficiency

  • Classic Haemophilia

  • Familial Haemophilia

  • Haemophilia

  • Hereditary Haemophilia

  • Subhaemophilia

  • Haemophilia Nos
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome

  • Mental Retardation, X-Linked, Syndromic 32

  • Mrxs32
Non-Syndromic X-Linked Intellectual Disability 72

  • Mrx72
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Syndromic X-Linked Intellectual Disability Shashi Type

  • Mental Retardation, X-Linked, Syndromic 11, Shashi Type

  • Mrxs11

  • Shashi X-Linked Mental Retardation Syndrome

  • Smrxs

  • Syndromic X-Linked Intellectual Disability Type 11

  • X-Linked Mental Retardation Shashi Type

  • Mental Retardation, X-Linked, Syndromic 11
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05146 FUNDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FUNDC2 RGD RGD:1560916
Bos taurus FUNDC2 VGNC VGNC:29144
Mus musculus FUNDC2 MGD MGI:1914641
Macaca mulatta FUNDC2 VGNC VGNC:81185
Felis catus FUNDC2 VGNC VGNC:62389
Canis familiaris FUNDC2 VGNC VGNC:41008
Others FUNDC2 NCBI