2. Gene
  3. SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2

Gene ID: 195814 | Gene type: protein coding

About SDR16C5

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,300,005-56,320,175 (from NCBI)

This gene has 3 transcripts (splice variants), 232 orthologues and 25 paralogues. Biased expression in skin (RPKM 15.8), esophagus (RPKM 9.7) and 7 other tissues.

Summary

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

SDR16C5 Products(3)

mRNA Protein Name
NM_001318049.2 NP_001304978.1 epidermal retinol dehydrogenase 2 isoform 1
NM_001318050.2 NP_001304979.1 epidermal retinol dehydrogenase 2 isoform 3
NM_138969.4 NP_620419.2 epidermal retinol dehydrogenase 2 isoform 2

SDR16C5 Protein Structure

adh_short

adh_short: short chain dehydrogenase (42 - 203)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

epidermal retinol dehydrogenase 2

epidermal retinal dehydrogenase 2

Related Diseases

Diseases Alias
Siberian Tick Typhus

North Asian Tick Typhus

Manchurian Typhus

North Asian Tick Fever

Rickettsia Sibirica Spotted Fever

Spotted Fever Group Rickettsiosis
Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12597 SDR16C5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SDR16C5 VGNC VGNC:77343
Bos taurus SDR16C5 VGNC VGNC:34395
Rattus norvegicus SDR16C5 RGD RGD:1565999
Canis familiaris SDR16C5 VGNC VGNC:45955
Felis catus SDR16C5 VGNC VGNC:64955
Mus musculus SDR16C5 MGD MGI:2668443