SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

Also Known as RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 195814

About SDR16C5

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,300,005-56,320,175 (from NCBI)

This gene has 3 transcripts (splice variants), 232 orthologues and 25 paralogues. Biased expression in skin (RPKM 15.8), esophagus (RPKM 9.7) and 7 other tissues.

Summary

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

SDR16C5 Products (3)

mRNA	Protein	Name
NM_001318049.2	NP_001304978.1	epidermal retinol dehydrogenase 2 isoform 1
NM_001318050.2	NP_001304979.1	epidermal retinol dehydrogenase 2 isoform 3
NM_138969.4	NP_620419.2	epidermal retinol dehydrogenase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16691198	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16691198	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	18926804	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16691198	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	12372410	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	16691198	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16691198	GOA
involved in retinal metabolic process	IDA IDA: Inferred from direct assay	18926804	GOA
involved in retinol metabolic process	IDA IDA: Inferred from direct assay	18926804	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	16691198	GOA
colocalizes with endoplasmic reticulum	IDA IDA: Inferred from direct assay	16691198	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	18926804	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16691198	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	16691198	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	16691198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDR16C5 Protein Structure

adh_short

0
100
200
309 a.a.

Protein Preferred Names	Protein Names
epidermal retinol dehydrogenase 2	epidermal retinal dehydrogenase 2

SDR16C5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SDR16C5	Q8N3Y7	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	SDR16C5	Q8N3Y7	FUNDC2	Homo sapiens	Q9BWH2	Validated Y2H	32296183
Intra	SDR16C5	Q8N3Y7	SENP2	Homo sapiens	Q9HC62	Validated Y2H	32296183
Intra	SDR16C5	Q8N3Y7	HSFX1	Homo sapiens	Q9UBD0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Siberian Tick Typhus	North Asian Tick Typhus Manchurian Typhus North Asian Tick Fever Rickettsia Sibirica Spotted Fever Spotted Fever Group Rickettsiosis
Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12597	SDR16C5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SDR16C5	VGNC	VGNC:77343
Bos taurus	SDR16C5	VGNC	VGNC:34395
Rattus norvegicus	SDR16C5	RGD	RGD:1565999
Canis familiaris	SDR16C5	VGNC	VGNC:45955
Felis catus	SDR16C5	VGNC	VGNC:64955
Mus musculus	SDR16C5	MGD	MGI:2668443
Others	SDR16C5	NCBI