SLC16A10 - solute carrier family 16 member 10 Gene

Also Known as TAT1; MCT10; PRO0813

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 117247

About SLC16A10

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,087,503-111,231,194 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 13 paralogues. Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues.

Summary

SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic Amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

SLC16A10 Products (1)

mRNA Protein Name
NM_018593.5 NP_061063.2 monocarboxylate transporter 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-phenylalanine transmembrane transporter activity IDA
IDA: Inferred from direct assay
11827462 GOA
enables L-tryptophan transmembrane transporter activity IDA
IDA: Inferred from direct assay
11827462 GOA
enables L-tyrosine transmembrane transporter activity IDA
IDA: Inferred from direct assay
11827462 GOA
enables aromatic amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
11827462 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables thyroid hormone transmembrane transporter activity IDA
IDA: Inferred from direct assay
18337592 GOA
Biological Process GO Annotation Evidence References Source
involved in aromatic amino acid transport IDA
IDA: Inferred from direct assay
11827462 GOA
involved in thyroid hormone transport IDA
IDA: Inferred from direct assay
18337592 GOA
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15918515 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18337592 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A10 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (84 - 378)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 10

  • MCT 10

SLC16A10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC16A10 Q8TF71 FUNDC2 Homo sapiens Q9BWH2
Validated Y2H
32296183
Intra
SLC16A10 Q8TF71 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
SLC16A10 Q8TF71 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allan-Herndon-Dudley Syndrome

  • AHDS

  • Allan-Herndon Syndrome

  • Monocarboxylate Transporter 8 Deficiency

  • MCT8 DEFICIENCY

  • Mental Retardation, X-Linked, With Hypotonia

  • Triiodothyronine Resistance

  • T3 Resistance

  • Mental Retardation And Muscular Atrophy

  • Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

  • Intellectual Disability And Muscular Atrophy

  • Monocarboxylate Transporter-8 Deficiency

  • T3 Resisitence

  • Triiodothyronine Resistence

  • X-Linked Intellectual Disability With Hypotonia

  • Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

  • Monocarboxylate Transporter 8 Deficiency

  • X-Linked Intellectual Disability-Hypotonia Syndrome
Deafness, Autosomal Recessive 62

  • DFNB62

  • Autosomal Recessive Nonsyndromic Deafness 62

  • Autosomal Recessive Deafness 62
Euthyroid Sick Syndrome

  • Euthyroid Sick Syndromes

  • Sick-Euthyroid Syndrome

  • Ess - [Euthyroid Sick Syndrome]

  • Low-T3 Syndrome

  • Ntis - [Non-Thyroidal Illness Syndrome]

  • Tscitus - [Thyroid Allostasis In Critical Illness, Tumours, Uraemia And Starvation]
Congenital Hypothyroidism

  • Cretinism

  • Neonatal Hypothyroidism

  • Ch

  • Cht

  • Congenital Myxedema

  • Myxedema, Congenital

  • Endemic Cretinism

  • Congenital Iodine-Deficiency Syndrome

  • Fetal Iodine Deficiency Syndrome

  • Congenital Iodine-Deficiency Hypothyroidism Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13019 SLC16A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC16A10 VGNC VGNC:46236
Bos taurus SLC16A10 VGNC VGNC:34684
Rattus norvegicus SLC16A10 RGD RGD:69197
Macaca mulatta SLC16A10 VGNC VGNC:103866
Mus musculus SLC16A10 MGD MGI:1919722
Others SLC16A10 NCBI