BMP-10
Bone morphogenetic protein 10 (BMP-10) is a cardiac-restricted TGF-β family ligand whose functions center on the heart and the vascular system rather than bone. During cardiogenesis, BMP-10 is expressed in the trabeculating ventricular myocardium and regulates chamber maturation, cardiac cushion formation and the trabeculation-compaction balance essential for ventricular wall morphogenesis. In adult life, BMP-10 is produced by the right atrium and acts on vascular endothelium through ALK1 and BMPR2-SMAD1/5 signaling to maintain quiescence of the pulmonary and systemic vasculature; together with BMP-9, it constitutes an endothelial angiostatic tone. Loss of BMP-10 bioavailability, via cleavage by the cardiac protease corin or dysregulated proprotein convertases, contributes to pulmonary arterial hypertension, atrial fibrillation and hereditary hemorrhagic telangiectasia-related vascular malformations. BMP-10 also suppresses endothelial inflammation, limits atherosclerotic lesion formation, and drives mesenchymal stem cell osteogenic differentiation in vitro, linking cardiokine biology with vascular medicine and bone research.
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BMP-10 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
