RHCG - Rh family C glycoprotein Gene

Also Known as RHGK; PDRC2; C15orf6; SLC42A3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51458

About RHCG

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,471,407-89,496,583 (from NCBI)

This gene has 7 transcripts (splice variants), 297 orthologues and 4 paralogues. Restricted expression toward esophagus (RPKM 1491.4).

Summary

Enables ammonium transmembrane transporter activity; ankyrin binding activity; and identical protein binding activity. Involved in ammonium transmembrane transport; cellular ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHCG Products (2)

mRNA	Protein	Name
NM_001321041.2	NP_001307970.1	ammonium transporter Rh type C
NM_016321.3	NP_057405.1	ammonium transporter Rh type C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ammonium channel activity	IDA IDA: Inferred from direct assay	14761968	GOA
enables ammonium channel activity	IGI IGI: Inferred from genetic interaction	11062476	GOA
enables ankyrin binding	IDA IDA: Inferred from direct assay	12719424	GOA
enables carbon dioxide transmembrane transporter activity	IDA IDA: Inferred from direct assay	24077989	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20457942	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ammonium transmembrane transport	IDA IDA: Inferred from direct assay	14761968	GOA
involved in ammonium transmembrane transport	IGI IGI: Inferred from genetic interaction	11062476	GOA
involved in intracellular monoatomic ion homeostasis	IDA IDA: Inferred from direct assay	14761968	GOA
involved in transepithelial ammonium transport	IDA IDA: Inferred from direct assay	18032481	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16928804	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16928804	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10852913	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHCG Protein Structure

Ammonium_transp

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
ammonium transporter Rh type C	Rh type C glycoprotein

RHCG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHCG	Q9UBD6	SCARB2	Homo sapiens	Q14108	Anti Tag CoIP	33961781
Intra	RHCG	Q9UBD6	SCARB2	Homo sapiens	Q14108	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced	Rh Deficiency Syndrome Rh Disease HDFNRH Rh Fetomaternal Incompatibility Rh-Null Syndrome
Overhydrated Hereditary Stomatocytosis	Ohs Potassium Sodium Disorder Of Erythrocyte OHST Stomatocytosis I Potassium-Sodium Disorder Of Erythrocyte Stomatocytosisiohst Hereditary, Overhydrated, Cation-Leak Stomatocytosis Overhydrated Cation Leak Stomatocytosis Stomatocytosis, Overhydrated Hereditary
Renal Tubular Acidosis	Acidosis Renal Tubular Acidosis, Renal Tubular Lightwood-Albright Syndrome Lightwood Syndrome Idiopathic Infantile Hypercalcemia - Mild Form Kidney Tubular Acidosis Renal Tubule Acidosis Kidney Acidosis Renal Acidosis Renal Hyperchloremic Acidosis Rta - [Renal Tubular Acidosis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11940	RHCG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHCG	RGD	RGD:727859
Bos taurus	RHCG	VGNC	VGNC:33938
Felis catus	RHCG	VGNC	VGNC:64608
Mus musculus	RHCG	MGD	MGI:1888517
Macaca mulatta	RHCG	VGNC	VGNC:84427
Canis familiaris	RHCG	VGNC	VGNC:45550
Others	RHCG	NCBI