SLC14A2 - solute carrier family 14 member 2 Gene

Also Known as UT2; UTA; UTR; HUT2; UT-A2; hUT-A6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8170

About SLC14A2

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:45,167,963-45,683,688 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues and 1 paralogue. Biased expression in kidney (RPKM 2.6), fat (RPKM 1.3) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the Urea Transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

SLC14A2 Products (3)

mRNA Protein Name
NM_001242692.2 NP_001229621.1 urea transporter 2
NM_001371319.1 NP_001358248.1 urea transporter 2
NM_007163.4 NP_009094.3 urea transporter 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cell adhesion molecule binding IDA
IDA: Inferred from direct assay
23620790 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17702749 GOA
enables urea transmembrane transporter activity IDA
IDA: Inferred from direct assay
8647271 GOA
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17702749 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17702749 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC14A2 Protein Structure

UT

UT: Urea transporter (117 - 420)

UT

UT: Urea transporter (579 - 883)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 920 a.a.
Protein Preferred Names Protein Names

urea transporter 2

  • solute carrier family 14 (urea transporter), member 2

SLC14A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SLC14A2 Q15849 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
SLC14A2 Q15849 TMEM97 Homo sapiens Q5BJF2
Complementation
32296183
Intra
SLC14A2 Q15849 TMEM97 Homo sapiens Q5BJF2
Validated Y2H
32296183
Intra
SLC14A2 Q15849 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
SLC14A2 Q15849 LRP10 Homo sapiens Q7Z4F1
Validated Y2H
32296183
Intra
SLC14A2 Q15849 LAT Homo sapiens O43561-2
Y2H Array
32296183
Intra
SLC14A2 Q15849 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bone Chondrosarcoma
Yaws

  • Frambesia

  • Frambesia Tropica

  • Bouba

  • Frambosie

  • Polypapilloma Tropicum

  • Thymosis

  • Endemic Treponematoses

  • Treponema Pertenue Infection

  • Pian

  • Framboesia

  • Framboesia Tropica

  • Castellani

  • Infection By Treponema Pertenue

  • Parangi

  • Framboesioma

  • Chancre Of Yaws

  • Primary Framboesia

  • Initial Lesions Of Yaws

  • Mother Yaw

  • Initial Framboesia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13011 SLC14A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC14A2 VGNC VGNC:77392
Mus musculus SLC14A2 MGD MGI:1351653
Bos taurus SLC14A2 VGNC VGNC:34678
Canis familiaris SLC14A2 VGNC VGNC:49648
Rattus norvegicus SLC14A2 RGD RGD:3689
Others SLC14A2 NCBI