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  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-gamma Receptor
  6. IFN-gamma R2

IFN-gamma R2

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IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2 is the signal-transducing chain of the IFN-gamma receptor. IFN-gamma R2 can associate with IFN-gamma R1 to form a functional receptor. Upon binding with IFN-gamma, IFNγR2 and IFNγR1 oligomerize and transphosphorylate[1]. Then, the downstream signaling components JAK1 and JAK2 are phosphorylated and activated, thereby creating a binding site for STAT1. Phosphorylated STAT1 leads to dimerization and translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54)[2]. Human IFN-gamma R2 consists of extracellular domain (S28-Q247), helical domain (V248-F268), and cytoplasmic domain (L269-L337). IFN-gamma R2 is constitutively expressed at low levels, and the expression is regulated by the state of cellular differentiation or activation. IFN-gamma R2 is highly expressed on myeloid cells, moderately on B cells and low on T cells. The expression of IFN-gamma R2 can dictate the Th1–Th2 phenotype switch and modulate the subsequent immune response[1][2]. IFN-gamma R2 is important for innating immune defense against mycobacterial infections. Defects in IFN-gamma R2 caused mendelian susceptibility to mycobacterial disease (MSMD)[2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7367
    IFN-gamma R2 Protein, Human (CHO)

    rHuIFN-γ Receptor II; IFNGR2; IFNGT1

    		Human CHO
    IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2 is the signal-transducing chain of the IFN-gamma receptor. IFN-gamma R2 forms the functional receptor with IFN-gamma R1. Upon binding with IFN-gamma, IFN-gamma R2 and IFN-gamma R1 oligomerize and transphosphorylate. Then, the downstream signaling components JAK1 and JAK2 are phosphorylated and activated, and STAT1 is phosphorylated. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54). IFN-gamma R2 Protein, Human (CHO) is a recombinant human IFN-gamma R2 (S28-Q247) without any tag, which is produced in CHO cells.
  • HY-P74852
    IFN-gamma R2 Protein, Mouse (HEK293, His)

    Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1

    		Mouse HEK293
    IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2 is the signal-transducing chain of the IFN-gamma receptor. IFN-gamma R2 forms the functional receptor with IFN-gamma R1. Upon binding with IFN-gamma, IFN-gamma R2 and IFN-gamma R1 oligomerize and transphosphorylate. Then, the downstream signaling components JAK1 and JAK2 are phosphorylated and activated, and STAT1 is phosphorylated. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54). IFN-gamma R2 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R2 (M1-V243) with C-terminal His tag, which is produced in HEK293 cells.
Cat. No. Product Name Effect Purity