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CLSTN3 - calsyntenin 3 Gene

Also Known as CSTN3; CDHR14; alcbeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9746

About CLSTN3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,129,093-7,158,945 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 203 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 35.5), kidney (RPKM 13.1) and 23 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of synapse assembly and positive regulation of synaptic transmission. Predicted to act upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and synapse assembly. Predicted to be located in postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

CLSTN3 Products (1)

mRNA	Protein	Name
NM_014718.4	NP_055533.2	calsyntenin-3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cell-cell adhesion mediator activity	IDA IDA: Inferred from direct assay	33101212	GOA
enables neurexin family protein binding	IDA IDA: Inferred from direct assay	33101212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-ascorbic acid metabolic process	IDA IDA: Inferred from direct assay	34673103	GOA
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	33101212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLSTN3 Protein Structure

Laminin_G_3

0
200
400
600
800
956 a.a.

Protein Preferred Names	Protein Names
calsyntenin-3	alc-beta

CLSTN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLSTN3	Q9BQT9	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vertebral Artery Occlusion	Occlusion And Stenosis Of Vertebral Artery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02842	CLSTN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLSTN3	VGNC	VGNC:60981
Canis familiaris	CLSTN3	VGNC	VGNC:39364
Bos taurus	CLSTN3	VGNC	VGNC:27468
Macaca mulatta	CLSTN3	VGNC	VGNC:71203
Rattus norvegicus	CLSTN3	RGD	RGD:621153
Mus musculus	CLSTN3	MGD	MGI:2178323
Others	CLSTN3	NCBI