TMEM120A - transmembrane protein 120A Gene

Also Known as NET29; TACAN; TMPIT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83862

About TMEM120A

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,986,831-75,994,595 (from NCBI)

This gene has 15 transcripts (splice variants), 251 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 47.7), adrenal (RPKM 45.0) and 25 other tissues.

Summary

Predicted to enable ion channel activity. Involved in fat cell differentiation; protein heterooligomerization; and protein homooligomerization. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM120A Products (3)

mRNA Protein Name
NM_001317803.2 NP_001304732.1 ion channel TACAN isoform 2
NM_001363462.2 NP_001350391.1 ion channel TACAN isoform 3
NM_031925.3 NP_114131.1 ion channel TACAN isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
26024229 GOA
involved in protein heterooligomerization IDA
IDA: Inferred from direct assay
26024229 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
26024229 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ion channel TACAN

  • transmembrane protein induced by tumor necrosis factor alpha

TMEM120A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM120A Q9BXJ8 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 DHRS7 Homo sapiens Q9Y394
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 DHRS7 Homo sapiens Q9Y394
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 LEPROT Homo sapiens O15243
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 LEPROT Homo sapiens O15243
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM88 Homo sapiens Q6PEY1
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM88 Homo sapiens Q6PEY1
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 TMEM88 Homo sapiens Q6PEY1
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 TSPAN18 Homo sapiens Q8WUV1
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 TSPAN18 Homo sapiens Q8WUV1
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
TMEM120A Q9BXJ8 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TMEM120A Q9BXJ8 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
TMEM120A Q9BXJ8 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14656 TMEM120A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM120A RGD RGD:1311474
Felis catus TMEM120A VGNC VGNC:66263
Macaca mulatta TMEM120A VGNC VGNC:79333
Mus musculus TMEM120A MGD MGI:2686991
Bos taurus TMEM120A VGNC VGNC:35956
Canis familiaris TMEM120A VGNC VGNC:54080
Others TMEM120A NCBI