LEPROT - leptin receptor overlapping transcript Gene

Also Known as LEPR; VPS55; OBRGRP; OB-RGRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54741

About LEPROT

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,420,668-65,436,007 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 33.5), kidney (RPKM 30.3) and 25 other tissues.

Summary

LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and Leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

LEPROT Products (3)

mRNA Protein Name
NM_001198681.2 NP_001185610.1 leptin receptor gene-related protein isoform 2
NM_001198683.2 NP_001185612.1 leptin receptor gene-related protein isoform 3
NM_017526.5 NP_059996.1 leptin receptor gene-related protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18042720 GOA
enables signaling receptor binding IDA
IDA: Inferred from direct assay
18042720 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of growth hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
19907080 GOA
involved in negative regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
18042720 GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
18042720 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18042720 GOA
located in endosome IDA
IDA: Inferred from direct assay
18042720 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEPROT Protein Structure

Vps55

Vps55: Vacuolar protein sorting 55 (7 - 125)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

leptin receptor gene-related protein

  • DnaJ (Hsp40) homolog, subfamily C, member 6

LEPROT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LEPROT O15243 SYNGR1 Homo sapiens O43759-2
Validated Y2H
32296183
Intra
LEPROT O15243 TMEM50B Homo sapiens P56557
Validated Y2H
32296183
Intra
LEPROT O15243 TMEM50B Homo sapiens P56557
Y2H Array
32296183
Intra
LEPROT O15243 TMEM50A Homo sapiens O95807
Validated Y2H
32296183
Intra
LEPROT O15243 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
LEPROT O15243 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
LEPROT O15243 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra
LEPROT O15243 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra
LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Validated Y2H
32296183
Intra
LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Y2H Array
32296183
Intra
LEPROT O15243 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra
LEPROT O15243 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
LEPROT O15243 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
LEPROT O15243 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
LEPROT O15243 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra
LEPROT O15243 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
LEPROT O15243 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
LEPROT O15243 GJA5 Homo sapiens P36382
Validated Y2H
32296183
Intra
LEPROT O15243 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Leptin

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07595 LEPROT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17371 Lepr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LEPROT VGNC VGNC:30844
Macaca mulatta LEPROT VGNC VGNC:74158
Mus musculus LEPROT MGD MGI:2687005
Canis familiaris LEPROT VGNC VGNC:42639
Rattus norvegicus LEPROT RGD RGD:621034
Others LEPROT NCBI