PLPPR1 - phospholipid phosphatase related 1 Gene

Also Known as LPPR1; PRG-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54886

Summary

This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate Phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Biased expression in brain (RPKM 18.9), kidney (RPKM 12.9) and 2 other tissues.

PLPPR1 Products (2)

mRNA Protein Name
NM_017753.3 NP_060223.2 phospholipid phosphatase-related protein type 1
NM_207299.2 NP_997182.1 phospholipid phosphatase-related protein type 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPPR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPPR1 Q8TBJ4 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
PLPPR1 Q8TBJ4 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 RAD23A Homo sapiens P54725
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 RAD23A Homo sapiens P54725
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 RAD23A Homo sapiens P54725
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
PLPPR1 Q8TBJ4 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
PLPPR1 Q8TBJ4 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
PLPPR1 Q8TBJ4 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra
PLPPR1 Q8TBJ4 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10734 PLPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown