DHRS7 - dehydrogenase/reductase 7 Gene

Also Known as CGI-86; SDR34C1; retDSR4; retSDR4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51635

About DHRS7

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,144,119-60,169,889 (from NCBI)

This gene has 11 transcripts (splice variants), 252 orthologues and 13 paralogues. Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are Enzymes that metabolize many different compounds, such as steroid Hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]

DHRS7 Products (4)

mRNA Protein Name
NM_001322280.2 NP_001309209.1 dehydrogenase/reductase SDR family member 7 isoform 2
NM_001322281.2 NP_001309210.1 dehydrogenase/reductase SDR family member 7 isoform 3
NM_001322282.2 NP_001309211.1 dehydrogenase/reductase SDR family member 7 isoform 4 precursor
NM_016029.4 NP_057113.1 dehydrogenase/reductase SDR family member 7 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
26466768 GOA
enables carbonyl reductase (NADPH) activity IDA
IDA: Inferred from direct assay
24246760 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
24246760 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
24246760 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS7 Protein Structure

adh_short

adh_short: short chain dehydrogenase (52 - 221)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

dehydrogenase/reductase SDR family member 7

  • dehydrogenase/reductase (SDR family) member 7

DHRS7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DHRS7 Q9Y394 TMEM120A Homo sapiens Q9BXJ8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03743 DHRS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03744 DHRS7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DHRS7 RGD RGD:1565002
Canis familiaris DHRS7 VGNC VGNC:39935
Bos taurus DHRS7 VGNC VGNC:28043
Felis catus DHRS7 VGNC VGNC:61471
Macaca mulatta DHRS7 VGNC VGNC:71690
Mus musculus DHRS7 MGD MGI:1913625
Others DHRS7 NCBI