SERINC1 - serine incorporator 1 Gene

Also Known as TDE2; TMS2; TDE1L; TMS-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57515

About SERINC1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,443,351-122,471,807 (from NCBI)

This gene has 1 transcript (splice variant), 219 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 241.4), adrenal (RPKM 145.5) and 25 other tissues.

Summary

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC1 Products (1)

mRNA	Protein	Name
NM_020755.4	NP_065806.1	serine incorporator 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERINC1 Protein Structure

Serinc

0
100
200
300
400
453 a.a.

Protein Preferred Names	Protein Names
serine incorporator 1	tumor differentially expressed protein 2

SERINC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SERINC1	Q9NRX5	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SERINC1	Q9NRX5	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SERINC1	Q9NRX5	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	SERINC1	Q9NRX5	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	SERINC1	Q9NRX5	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	SERINC1	Q9NRX5	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	SERINC1	Q9NRX5	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SERINC1	Q9NRX5	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SERINC1	Q9NRX5	PAX8	Homo sapiens	Q06710	TAP	20195357
Intra	SERINC1	Q9NRX5	PAX8	Homo sapiens	Q06710	Display Tech	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Paraplegia 50, Autosomal Recessive	Hereditary Spastic Paraplegia 50 SPG50 Ap-4 Deficiency Syndrome Ap-4-Associated Hereditary Spastic Paraplegia Adaptor Protein Complex 4 Deficiency Cerebral Palsy, Spastic Quadriplegic, 3, Formerly Cpsq3, Formerly Autosomal Recessive Spastic Paraplegia 50 Cpsq3 Spastic Quadriplegic Cerebral Palsy 3 Ap-4 Deficiency Ap-4-Associated Hsp Paraplegia, Spastic, Autosomal Recessive, Type 50 Spastic Paraplegia-50, Autosomal Recessive
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12690	SERINC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERINC1	RGD	RGD:727843
Canis familiaris	SERINC1	VGNC	VGNC:46019
Macaca mulatta	SERINC1	VGNC	VGNC:77226
Felis catus	SERINC1	VGNC	VGNC:65017
Mus musculus	SERINC1	MGD	MGI:1926228
Others	SERINC1	NCBI