FFAR3 - free fatty acid receptor 3 Gene

Also Known as FFA3R; GPR41; GPR42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2865

About FFAR3

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,358,151-35,360,489 (from NCBI)

This gene has 2 transcripts (splice variants), 339 orthologues and 15 paralogues. Biased expression in appendix (RPKM 1.2), fat (RPKM 0.6) and 13 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FFAR3 Products (1)

mRNA	Protein	Name
NM_005304.5	NP_005295.1	free fatty acid receptor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	12496283	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12496283	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14722361	GOA
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	12496283	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18801738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FFAR3 Protein Structure

7tm_1

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
free fatty acid receptor 3	G-protein coupled receptor 41

FFAR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FFAR3	O14843	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	FFAR3	O14843	TOMM6	Homo sapiens	Q96B49	Validated Y2H	32296183
Intra	FFAR3	O14843	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	FFAR3	O14843	LTC4S	Homo sapiens	Q16873	Validated Y2H	32296183
Intra	FFAR3	O14843	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	FFAR3	O14843	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	FFAR3	O14843	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	FFAR3	O14843	SERINC1	Homo sapiens	Q9NRX5	Validated Y2H	32296183
Intra	FFAR3	O14843	COMT	Homo sapiens	P21964	Validated Y2H	32296183
Intra	FFAR3	O14843	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	FFAR3	O14843	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32814053
Intra	FFAR3	O14843	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32814053
Intra	FFAR3	O14843	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Pooling	32814053
Intra	FFAR3	O14843	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	FFAR3	O14843	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	FFAR3	O14843	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	FFAR3	O14843	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	FFAR3	O14843	LAT	Homo sapiens	O43561-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FFAR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810883	GPR41 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diversion Colitis
Anaerobic Meningitis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163531	GPR41 modulator 2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FFAR3	MGD	MGI:2685324
Rattus norvegicus	FFAR3	RGD	RGD:1311035