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TEX264 - testis expressed 264, ER-phagy receptor Gene

Also Known as ZSIG11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51368

About TEX264

This gene has 16 transcripts (splice variants) and 180 orthologues. Ubiquitous expression in testis (RPKM 25.1), kidney (RPKM 16.6) and 25 other tissues.

Summary

Enables signaling receptor activity. Involved in protein-DNA covalent cross-linking repair. Acts upstream of or within reticulophagy. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. [provided by Alliance of Genome Resources, Apr 2022]

TEX264 Products (6)

mRNA	Protein	Name
NM_001129884.3	NP_001123356.1	testis-expressed protein 264 isoform 1
NM_001243725.2	NP_001230654.1	testis-expressed protein 264 isoform 1
NM_001243726.2	NP_001230655.1	testis-expressed protein 264 isoform 1
NM_001243727.3	NP_001230656.1	testis-expressed protein 264 isoform 2
NM_001278195.2	NP_001265124.1	testis-expressed protein 264 isoform 1
NM_015926.6	NP_057010.1	testis-expressed protein 264 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	31006538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein-DNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	32152270	GOA
acts upstream of or within reticulophagy	IDA IDA: Inferred from direct assay	31006538	GOA
involved in reticulophagy	IMP IMP: Inferred from mutant phenotype	31006537	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome membrane	IDA IDA: Inferred from direct assay	31006537	GOA
located in cytosol	IDA IDA: Inferred from direct assay	32152270	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	31006537	GOA
located in nucleus	IDA IDA: Inferred from direct assay	32152270	GOA
located in replication fork	IDA IDA: Inferred from direct assay	32152270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEX264 Protein Structure

GyrI-like

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
testis-expressed protein 264	testis expressed gene 264

TEX264 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TEX264	Q9Y6I9	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	ADGRG3	Homo sapiens	Q86Y34	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	ADGRG3	Homo sapiens	Q86Y34	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	LHFPL4	Homo sapiens	Q7Z7J7	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	LHFPL4	Homo sapiens	Q7Z7J7	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CLN6	Homo sapiens	Q9NWW5	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	CLN6	Homo sapiens	Q9NWW5	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CLDN2	Homo sapiens	P57739	Y2H Prey Pooling	32296183
Intra	TEX264	Q9Y6I9	CLDN2	Homo sapiens	P57739	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	31515488
Intra	TEX264	Q9Y6I9	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	25416956
Intra	TEX264	Q9Y6I9	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183
Intra	TEX264	Q9Y6I9	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TEX264 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89920	TEX264 Antibody (YA9264)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Hereditary Sensory And Autonomic Neuropathy Type 1	Hereditary Sensory And Autonomic Neuropathy Type I Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome Hsan1e Hsan1 Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy Hsn1e Hsnie Hereditary Sensory Neuropathy Type Ie Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome Hereditary Sensory And Autonomic Neuropathy Type Ie Hereditary Sensory And Autonomic Neuropathy Type 1e Hereditary Sensory Neuropathy With Hearing Loss And Dementia Dnmt1-Complex Disorder Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss Hsn Ie Hereditary Sensory Autonomic Neuropathy, Type 1 Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174066	SI-W052		98.0%	Unkown
HY-RS14395	TEX264 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21956	Tex264 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28473	Tex264 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TEX264	VGNC	VGNC:35765
Rattus norvegicus	TEX264	RGD	RGD:1359353
Macaca mulatta	TEX264	VGNC	VGNC:79841
Felis catus	TEX264	VGNC	VGNC:66099
Mus musculus	TEX264	MGD	MGI:1096570
Canis familiaris	TEX264	VGNC	VGNC:47271
Others	TEX264	NCBI