ADGRG3 - adhesion G protein-coupled receptor G3 Gene

Also Known as PB99; GPR97; PGR26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 222487

About ADGRG3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,665,629-57,689,378 (from NCBI)

This gene has 7 transcripts (splice variants), 271 orthologues and 42 paralogues. Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADGRG3 Products (2)

mRNA	Protein	Name
NM_001308360.2	NP_001295289.1	adhesion G protein-coupled receptor G3 isoform 2
NM_170776.5	NP_740746.4	adhesion G protein-coupled receptor G3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22575658	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24178298	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	22575658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRG3 Protein Structure

GPS

7tm_2

0
100
200
300
400
500
549 a.a.

Protein Preferred Names	Protein Names
adhesion G protein-coupled receptor G3	G protein-coupled receptor 97

ADGRG3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADGRG3	Q86Y34	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	ADGRG3	Q86Y34	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vibratory Urticaria	Vibratory Angioedema Dermodistortive Urticaria VBU Ddu Angioedema, Vibratory
Polymicrogyria, Bilateral Frontoparietal	Bilateral Frontoparietal Polymicrogyria BFPP Cerebellar Ataxia With Neuronal Migration Defect
Congenital Epulis	Gingival Neoplasms Congenital Epulides Congenital Gingival Cell Tumor Congenital Granular Cell Tumor Neumann Tumor
Epulis	Epulides Gingival Polyp Polyp Of Gum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00356	ADGRG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADGRG3	RGD	RGD:1305674
Macaca mulatta	ADGRG3	VGNC	VGNC:69606
Canis familiaris	ADGRG3	VGNC	VGNC:37645
Mus musculus	ADGRG3	MGD	MGI:1859670
Bos taurus	ADGRG3	VGNC	VGNC:25667
Felis catus	ADGRG3	VGNC	VGNC:59635
Others	ADGRG3	NCBI