CLDN2 - claudin 2 Gene

Also Known as OAZON

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9075

About CLDN2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,900,164-106,930,861 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues, 22 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 67.4), gall bladder (RPKM 59.4) and 4 other tissues.

Summary

This gene product belongs to the Claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]

CLDN2 Products (3)

mRNA	Protein	Name
NM_001171092.1	NP_001164563.1	claudin-2
NM_001171095.2	NP_001164566.1	claudin-2
NM_020384.4	NP_065117.1	claudin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	36008380	GOA
enables paracellular tight junction channel activity	IDA IDA: Inferred from direct assay	20460438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25323998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in paracellular transport	IDA IDA: Inferred from direct assay	20460438	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	21415414	GOA
located in tight junction	IDA IDA: Inferred from direct assay	20460438	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN2 Protein Structure

PMP22_Claudin

0
100
200
230 a.a.

Protein Preferred Names	Protein Names
claudin-2	SP82

CLDN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLDN2	P57739	ADAM33	Homo sapiens	Q08AM2	Validated Y2H	32296183
Intra	CLDN2	P57739	GRM2	Homo sapiens	Q14416	Validated Y2H	32296183
Intra	CLDN2	P57739	CSGALNACT2	Homo sapiens	Q8N6G5	Validated Y2H	32296183
Intra	CLDN2	P57739	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	CLDN2	P57739	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CLDN2	P57739	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	CLDN2	P57739	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	CLDN2	P57739	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	CLDN2	P57739	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CLDN2	P57739	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CLDN2	P57739	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	CLDN2	P57739	BTN3A2	Homo sapiens	P78410	Y2H Array	32296183
Intra	CLDN2	P57739	BTN3A2	Homo sapiens	P78410	Validated Y2H	32296183
Intra	CLDN2	P57739	BTN3A2	Homo sapiens	P78410	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	CLDN2	P57739	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CLDN2	P57739	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	IL27RA	Homo sapiens	Q6UWB1	Validated Y2H	32296183
Intra	CLDN2	P57739	IL27RA	Homo sapiens	Q6UWB1	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	IL27RA	Homo sapiens	Q6UWB1	Y2H Array	32296183
Intra	CLDN2	P57739	AP2M1	Homo sapiens	Q96CW1	IF	34964704
Intra	CLDN2	P57739	AP2M1	Homo sapiens	Q96CW1	Anti Tag CoIP	34964704
Intra	CLDN2	P57739	AP2M1	Homo sapiens	Q96CW1	Anti Bait CoIP	34964704
Intra	CLDN2	P57739	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	37460613
Intra	CLDN2	P57739	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CLDN2	P57739	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CLDN2	P57739	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	CLDN2	P57739	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	CLDN2	P57739	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	CLDN2	P57739	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CLDN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85778	Claudin-2 Antibody (YA5470)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P85797	Claudin-2 Antibody (YA5489)	IHC-P, WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Azoospermia, Obstructive, With Nephrolithiasis	OAZON
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease 20	IBD20
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Chemical Colitis
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Autoimmune Disease Of Gastrointestinal Tract
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2468	Xylobiose	Inhibitor	98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLDN2	MGD	MGI:1276110
Bos taurus	CLDN2	VGNC	VGNC:27410
Felis catus	CLDN2	VGNC	VGNC:60934
Rattus norvegicus	CLDN2	RGD	RGD:1560247
Canis familiaris	CLDN2	VGNC	VGNC:39316
Others	CLDN2	NCBI