Xylobiose
Based on 1 Customer Validation
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 6860-47-5
- 分子式: C10H18O9
- 分子量:282.24
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Claudin-2 |
HSP27 |
Xylobiose (5-20 mg/mL; 3-24 h) down-regulates the gene and protein expression of Claudin 2 in human intestinal Caco-2 cells, up-regulates the gene and protein expression of heat shock proteins HSP27 and HSP70, and enhances the transepithelial electrical resistance (TER) of the cell monolayer, which may strengthen the intestinal barrier function by regulating signaling pathways such as PI3K[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human intestinal Caco-2 cells
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Concentration:5, 10, 20 mg/mL
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Incubation Time:3, 6, 12, 24 h
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Result:Downregulated CLDN2 expression, which is involved in paracellular permeability, and upregulated HSP27 and HSP70 expression, which are cytoprotective proteins. These changes indicated an improvement in the cell's functional state rather than a direct impact on cell viability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Dosage:
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Administration:
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Result:Animal Model: C57BL/KsJ-db/db male mice (17-24 g, 5-week-old), type 2 diabetes model induced by genetic factors[2] - Dosage (solvent): 5% xylobiose replacing sucrose in the diet (dissolved in the diet) - Administration: Dietary intake, daily, for 6 weeks - Result: Did not affect the body weight change compared with the diabetic control group, while significantly reduced food and water intake.
化学情報
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CAS 番号 6860-47-5
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性状 Solid
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分子量 282.24
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分子式 C10H18O9
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Color White to off-white
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SMILES
O=C[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1[C@@H]([C@H]([C@H](O)CO1)O)O
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別名
Xylobiose; 1,4-β-D-Xylobiose; 1,4-D-Xylobiose
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : ≥ 125 mg/mL (442.89 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (354.31 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Rini DM, et al. Xylobiose treatment strengthens intestinal barrier function by regulating claudin 2 and heat shock protein 27 expression in human Caco-2 cells. J Sci Food Agric. 2024 Mar 15;104(4):2518-2525. [Content Brief]
[2]. Lim E, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016 Dec 5;8(12):791 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.5431 mL | 17.7154 mL | 35.4308 mL | 88.5771 mL |
| 5 mM | 0.7086 mL | 3.5431 mL | 7.0862 mL | 17.7154 mL | |
| 10 mM | 0.3543 mL | 1.7715 mL | 3.5431 mL | 8.8577 mL | |
| 15 mM | 0.2362 mL | 1.1810 mL | 2.3621 mL | 5.9051 mL | |
| 20 mM | 0.1772 mL | 0.8858 mL | 1.7715 mL | 4.4289 mL | |
| 25 mM | 0.1417 mL | 0.7086 mL | 1.4172 mL | 3.5431 mL | |
| 30 mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.9526 mL | |
| 40 mM | 0.0886 mL | 0.4429 mL | 0.8858 mL | 2.2144 mL | |
| 50 mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.7715 mL | |
| 60 mM | 0.0591 mL | 0.2953 mL | 0.5905 mL | 1.4763 mL | |
| 80 mM | 0.0443 mL | 0.2214 mL | 0.4429 mL | 1.1072 mL | |
| 100 mM | 0.0354 mL | 0.1772 mL | 0.3543 mL | 0.8858 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Xylobiose 関連分類
HY-N2468 関連分類
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