EMP1 - epithelial membrane protein 1 Gene

Also Known as TMP; CL-20; EMP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2012

About EMP1

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:13,196,726-13,219,941 (from NCBI)

This gene has 12 transcripts (splice variants), 269 orthologues and 10 paralogues. Biased expression in esophagus (RPKM 1426.7), gall bladder (RPKM 194.7) and 2 other tissues.

Summary

Involved in bleb assembly and cell death. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EMP1 Products (1)

mRNA	Protein	Name
NM_001423.3	NP_001414.1	epithelial membrane protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12107182	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	12107182	GOA
involved in bleb assembly	IDA IDA: Inferred from direct assay	12107182	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12107182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMP1 Protein Structure

PMP22_Claudin

0
100
157 a.a.

Protein Preferred Names	Protein Names
epithelial membrane protein 1	tumor-associated membrane protein

EMP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EMP1	P54849	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	EMP1	P54849	LSMEM2	Homo sapiens	Q8N112	Y2H Array	32296183
Intra	EMP1	P54849	LSMEM2	Homo sapiens	Q8N112	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	EMP1	P54849	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	EMP1	P54849	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	EMP1	P54849	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	EMP1	P54849	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	EMP1	P54849	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	EMP1	P54849	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	EMP1	P54849	ISLR2	Homo sapiens	Q6UXK2	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ISLR2	Homo sapiens	Q6UXK2	Validated Y2H	32296183
Intra	EMP1	P54849	ISLR2	Homo sapiens	Q6UXK2	Y2H Array	32296183
Intra	EMP1	P54849	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	EMP1	P54849	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	EMP1	P54849	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	EMP1	P54849	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	EMP1	P54849	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	EMP1	P54849	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	EMP1	P54849	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	EMP1	P54849	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	EMP1	P54849	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	EMP1	P54849	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	EMP1	P54849	LRRC3B	Homo sapiens	Q96PB8	Validated Y2H	32296183
Intra	EMP1	P54849	LRRC3B	Homo sapiens	Q96PB8	Y2H Array	32296183
Intra	EMP1	P54849	CORIN	Homo sapiens	Q9Y5Q5	Validated Y2H	32296183
Intra	EMP1	P54849	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	EMP1	P54849	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TBXA2R	Homo sapiens	Q0VAB0	Validated Y2H	32296183
Intra	EMP1	P54849	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	EMP1	P54849	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	EMP1	P54849	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	EMP1	P54849	TMEM160	Homo sapiens	Q9NX00	Validated Y2H	32296183
Intra	EMP1	P54849	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	EMP1	P54849	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	EMP1	P54849	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	EMP1	P54849	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	CXCR2	Homo sapiens	P25025	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	CXCR2	Homo sapiens	P25025	Y2H Array	32296183
Intra	EMP1	P54849	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	EMP1	P54849	LPAR6	Homo sapiens	P43657	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	LPAR6	Homo sapiens	P43657	Y2H Array	32296183
Intra	EMP1	P54849	LAPTM4B	Homo sapiens	Q86VI4	Validated Y2H	32296183
Intra	EMP1	P54849	LAPTM4B	Homo sapiens	Q86VI4	Y2H Array	32296183
Intra	EMP1	P54849	LAPTM4B	Homo sapiens	Q86VI4	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	EMP1	P54849	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	EMP1	P54849	CD3G	Homo sapiens	P09693	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	CD3G	Homo sapiens	P09693	Y2H Array	32296183
Intra	EMP1	P54849	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	EMP1	P54849	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	EMP1	P54849	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	EMP1	P54849	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	EMP1	P54849	JPH1	Homo sapiens	Q9HDC5	Y2H Array	32296183
Intra	EMP1	P54849	JPH1	Homo sapiens	Q9HDC5	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	JPH1	Homo sapiens	Q9HDC5	Validated Y2H	32296183
Intra	EMP1	P54849	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	EMP1	P54849	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	EMP1	P54849	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	EMP1	P54849	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	EMP1	P54849	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ANKS6	Homo sapiens	Q68DC2	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ANKS6	Homo sapiens	Q68DC2	Validated Y2H	32296183
Intra	EMP1	P54849	ANKS6	Homo sapiens	Q68DC2	Y2H Array	32296183
Intra	EMP1	P54849	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	32296183
Intra	EMP1	P54849	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	EMP1	P54849	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	EMP1	P54849	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	32296183
Intra	EMP1	P54849	MS4A7	Homo sapiens	Q9GZW8	Validated Y2H	32296183
Intra	EMP1	P54849	MS4A7	Homo sapiens	Q9GZW8	Y2H Array	32296183
Intra	EMP1	P54849	MS4A7	Homo sapiens	Q9GZW8	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
Intra	EMP1	P54849	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
Intra	EMP1	P54849	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	EMP1	P54849	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	EMP1	P54849	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	EMP1	P54849	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
Intra	EMP1	P54849	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	EMP1	P54849	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	25416956
Intra	EMP1	P54849	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	EMP1	P54849	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	EMP1	P54849	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	EMP1	P54849	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	EMP1	P54849	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	EMP1	P54849	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	EMP1	P54849	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ANK1	Homo sapiens	P16157-17	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	ANK1	Homo sapiens	P16157-17	Y2H Array	32296183
Intra	EMP1	P54849	HTR2C	Homo sapiens	P28335	Y2H Prey Pooling	32296183
Intra	EMP1	P54849	HTR2C	Homo sapiens	P28335	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Endobronchial Lipoma
Perineocele
Dental Abscess
Blount'S Disease	Blount Disease Tibia Vara Osteochondrosis Deformans Tibiae Osteochondrosis Deformans Tibiae, Familial Infantile Type Familial Infantile Type Osteochondrosis Deformans Tibiae Blount-Barber Syndrome Erlacher-Blount Syndrome Infantile Tibia Vara Tibia Vara Blount Blount Disease, Infantile
Hypophosphatemic Rickets, X-Linked Dominant	X-Linked Hypophosphatemia Xlh Vitamin D-Resistant Rickets, X-Linked X-Linked Hypophosphatemic Rickets XLHR Hyp Hypophosphatemic Vitamin D-Resistant Rickets Hpdr X-Linked Dominant Hypophosphatemic Rickets Familial Hypophosphatemic Rickets Hypophosphatemia, X-Linked Hypophosphatemia, Vitamin D-Resistant Rickets Hypophosphatemic Rickets X-Linked Dominant X-Linked Vitamin D-Resistant Rickets Hypophophatemia, X-Linked Hypophophatemic Vitamin D-Resistant Rickets Hypophosphatemia X-Linked Vitamin D-Resistant Rickets X-Linked Vitamin D-Resistant Rickets Rickets, X-Linked Hypophosphatemic
Progressive Myoclonus Epilepsy 9	Emp9 Pme Type 9 Progressive Myoclonic Epilepsy Due To Lmnb2 Deficiency Progressive Myoclonus Epilepsy Type 9
Enthesopathy	Rheumatism
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Hypophosphatemic Rickets With Hypercalciuria, Hereditary	Hereditary Hypophosphatemic Rickets With Hypercalciuria HHRH Hypophosphatemic Rickets With Hypercalciuria Hypercalciuric Rickets
Conjunctival Deposit
Hypophosphatemic Rickets, Autosomal Dominant	Autosomal Dominant Hypophosphatemic Rickets ADHR Autosomal Dominant Hypophosphatemia Vitamin D-Resistant Rickets, Autosomal Dominant Hypophosphatemia, Autosomal Dominant Autosomal Dominant Vitamin D-Resistant Rickets Rickets, Hypophosphatemic, Autosomal Dominant
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Subacute Lymphocytic Thyroiditis
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1	Hypophosphatemic Nephrolithiasis/Osteoporosis 1 NPHLOP1 Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1 Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1	Hyperphosphatemic Familial Tumoral Calcinosis Hftc Hyperostosis-Hyperphosphatemia Syndrome Familial Hyperphosphatemic Tumoral Calcinosis/Hyperphosphatemic Hyperostosis Syndrome Tumoral Calcinosis, Hyperphosphatemic, Familial Phptc Lipocalcinogranulomatosis Morbus Teutschlaender Hhs Hyperostosis With Hyperphosphatemia Cortical Hyperostosis With Hyperphosphatemia Primary Hyperphosphatemic Tumoral Calcinosis Familial Tumoral Calcinosis HFTC1 Hypercalcemic Tumoral Calcinosis Hyperphosphatemia Hyperostosis Hyperphosphatemia Hyperostosis Syndrome Hyperphosphatemia Tumoral Calcinosis Tumoral Calcinosis Calcinosis, Tumoral, With Hyperphosphatemia Tumoral Calcinosis, Primary Hyperphosphatemic Teutschlaender Disease, Familial Familial Teutschlaender Disease Tumoral Calcinosis With Hyperphosphatemia Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome Ftc/Hhs Familial Tumoral Calcinosis With Hyperphosphatemia Teutschlaender Disease Tumoral Calcinosis Primary Hyperphosphatemic Calcinosis, Tumoral, Hyperphosphatemic, Familial
Schimmelpenning-Feuerstein-Mims Syndrome	Nevus Sebaceus Of Jadassohn Organoid Nevus Phakomatosis Linear Nevus Sebaceous Syndrome Sfm Syndrome Jadassohn Nevus Phakomatosis Jnp Schimmelpenning Syndrome Solomon Syndrome SFM Linear Sebaceous Nevus Syndrome Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic Nevus Sebaceus Syndrome Organoid Nevus Syndrome Schimmelpenning Feuerstein Mims Syndrome Sebaceous Nevus Syndrome, Linear Epidermal Nevus Syndrome, Formerly Sebaceous Nevus Syndrome Linear Linear Nevus Sebaceus Syndrome Epidermal Nevus Syndrome Ss Nevus Sebaceous
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04359	EMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17489	Emp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23947	Emp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EMP1	VGNC	VGNC:40352
Rattus norvegicus	EMP1	RGD	RGD:2552
Mus musculus	EMP1	MGD	MGI:107941
Macaca mulatta	EMP1	VGNC	VGNC:72214
Bos taurus	EMP1	VGNC	VGNC:28481
Others	EMP1	NCBI