TSPO2 - translocator protein 2 Gene

Also Known as BZRPL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222642

About TSPO2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,041,386-41,044,337 (from NCBI)

This gene has 3 transcripts (splice variants), 165 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 6.9) and testis (RPKM 0.2).

Summary

Predicted to enable Cholesterol binding activity. Involved in amino acid import across plasma membrane. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TSPO2 Products (2)

mRNA Protein Name
NM_001010873.3 NP_001010873.1 translocator protein 2
NM_001159726.1 NP_001153198.1 translocator protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5-aminolevulinic acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
31989647 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in 5-aminolevulinic acid import across plasma membrane IMP
IMP: Inferred from mutant phenotype
31989647 GOA
involved in import across plasma membrane IDA
IDA: Inferred from direct assay
27641616 GOA
Cellular Component GO Annotation Evidence References Source
located in organelle membrane IDA
IDA: Inferred from direct assay
27641616 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
27641616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPO2 Protein Structure

TspO_MBR

TspO_MBR: TspO/MBR family (7 - 154)

  • 0
  • 100
  • 170 a.a.
Protein Preferred Names Protein Names

translocator protein 2

  • benzodiazapine receptor (peripheral)-like 1

TSPO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSPO2 Q5TGU0 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 MARCHF2 Homo sapiens Q9P0N8
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 GGT7 Homo sapiens Q9UJ14
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 GGT7 Homo sapiens Q9UJ14
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 GGT7 Homo sapiens Q9UJ14
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 AHNAK2 Homo sapiens Q8IVF2-3
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC34A2 Homo sapiens O95436-2
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC34A2 Homo sapiens O95436-2
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 DKK4 Homo sapiens Q9UBT3
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 DKK4 Homo sapiens Q9UBT3
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 DKK4 Homo sapiens Q9UBT3
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CD69 Homo sapiens Q07108
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 MFSD6 Homo sapiens Q6ZSS7
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 MFSD6 Homo sapiens Q6ZSS7
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 LRRC59 Homo sapiens Q96AG4
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 LRRC59 Homo sapiens Q96AG4
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 LRRC59 Homo sapiens Q96AG4
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC41A3 Homo sapiens Q96GZ6
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 SLC41A3 Homo sapiens Q96GZ6
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 SLC41A3 Homo sapiens Q96GZ6
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra
TSPO2 Q5TGU0 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ERP29 Homo sapiens P30040
Y2H Array
32296183
Intra
TSPO2 Q5TGU0 ERP29 Homo sapiens P30040
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Intra
TSPO2 Q5TGU0 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15178 TSPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TSPO2 RGD RGD:1594018
Bos taurus TSPO2 VGNC VGNC:55923
Felis catus TSPO2 VGNC VGNC:102542
Canis familiaris TSPO2 VGNC VGNC:49105
Mus musculus TSPO2 MGD MGI:1917276
Macaca mulatta TSPO2 VGNC VGNC:83960
Others TSPO2 NCBI