SLC41A3 - solute carrier family 41 member 3 Gene

Also Known as SLC41A1-L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54946

About SLC41A3

Cytogenetic location: 3q21.2-q21.3 Genomic coordinates (GRCh38): 3:126,006,357-126,101,520 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 23.3), ovary (RPKM 19.3) and 25 other tissues.

Summary

Predicted to enable cation transmembrane transporter activity. Predicted to be involved in cation transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC41A3 Products (5)

mRNA Protein Name
NM_001008485.2 NP_001008485.2 solute carrier family 41 member 3 isoform 1
NM_001008486.2 NP_001008486.2 solute carrier family 41 member 3 isoform 3
NM_001008487.2 NP_001008487.1 solute carrier family 41 member 3 isoform 4
NM_001164475.2 NP_001157947.1 solute carrier family 41 member 3 isoform 5
NM_017836.4 NP_060306.4 solute carrier family 41 member 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables magnesium:sodium antiporter activity IDA
IDA: Inferred from direct assay
27302215 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial magnesium ion transmembrane transport IDA
IDA: Inferred from direct assay
27302215 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27302215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC41A3 Protein Structure

MgtE

MgtE: Divalent cation transporter (106 - 240)

MgtE

MgtE: Divalent cation transporter (318 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
Protein Preferred Names Protein Names

solute carrier family 41 member 3

  • SLC41A1-like 2

SLC41A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC41A3 Q96GZ6 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra
SLC41A3 Q96GZ6 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra
SLC41A3 Q96GZ6 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra
SLC41A3 Q96GZ6 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
SLC41A3 Q96GZ6 SUFU Homo sapiens Q9UMX1
Y2H Prey Pooling
32296183
Intra
SLC41A3 Q96GZ6 SUFU Homo sapiens Q9UMX1
Validated Y2H
32296183
Intra
SLC41A3 Q96GZ6 SUFU Homo sapiens Q9UMX1
Y2H Array
32296183
Intra
SLC41A3 Q96GZ6 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
SLC41A3 Q96GZ6 NHERF4 Homo sapiens Q86UT5
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypomagnesemia 1, Intestinal

  • Intestinal Hypomagnesemia 1

  • HOMG1

  • Hypomagnesemia With Secondary Hypocalcemia

  • Hsh

  • Hypomagnesemic Tetany

  • Intestinal Hypomagnesemia With Secondary Hypocalcemia

  • Homg

  • Hypomagnesemia Caused By Selective Magnesium Malabsorption

  • Hypomagnesemia Intestinal Type 1

  • Primary Hypomagnesemia With Secondary Hypocalcemia

  • Phsh

  • Hypomagnesemia, Intestinal, With Secondary Hypocalcemia

  • Familial Primary Hypomagnesemia With Hypocalcuria

  • Hypomagnesemia 1

  • Hypomagnesmic Tetany
Primary Hypomagnesemia

  • Familial Primary Hypomagnesemia

  • Homg

  • Primary Familial Hypomagnesemia

  • Genetic Primary Hypomagnesemia

  • Hypomagnesemia 1, Intestinal
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13247 SLC41A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC41A3 VGNC VGNC:46414
Bos taurus SLC41A3 VGNC VGNC:58412
Rattus norvegicus SLC41A3 RGD RGD:1589573
Mus musculus SLC41A3 MGD MGI:1918949
Macaca mulatta SLC41A3 VGNC VGNC:77586
Others SLC41A3 NCBI