MFSD6 - major facilitator superfamily domain containing 6 Gene

Also Known as MMR2; hMMR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54842

About MFSD6

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,407,576-190,502,314 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.0), thyroid (RPKM 22.9) and 23 other tissues.

Summary

Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MFSD6 Products (9)

mRNA Protein Name
NM_001375986.1 NP_001362915.1 major facilitator superfamily domain-containing protein 6 isoform a
NM_001375987.1 NP_001362916.1 major facilitator superfamily domain-containing protein 6 isoform a
NM_001375988.1 NP_001362917.1 major facilitator superfamily domain-containing protein 6 isoform a
NM_001375989.1 NP_001362918.1 major facilitator superfamily domain-containing protein 6 isoform b
NM_001375990.1 NP_001362919.1 major facilitator superfamily domain-containing protein 6 isoform b
NM_001375992.1 NP_001362921.1 major facilitator superfamily domain-containing protein 6 isoform b
NM_001375993.1 NP_001362922.1 major facilitator superfamily domain-containing protein 6 isoform c
NM_001375994.1 NP_001362923.1 major facilitator superfamily domain-containing protein 6 isoform d
NM_017694.4 NP_060164.3 major facilitator superfamily domain-containing protein 6 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD6 Protein Structure

MFS_1_like

MFS_1_like: MFS_1 like family (70 - 142)

MFS_1

MFS_1: Major Facilitator Superfamily (450 - 643)

  • 0
  • 200
  • 400
  • 600
  • 791 a.a.
Protein Preferred Names Protein Names

major facilitator superfamily domain-containing protein 6

  • macrophage MHC class I receptor 2 homolog

MFSD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MFSD6 Q6ZSS7 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SDC3 Homo sapiens A0A0S2Z4U3
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 AQP7 Homo sapiens Q6P5T0
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 AQP7 Homo sapiens Q6P5T0
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 TMEM179B Homo sapiens Q7Z7N9
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 MFSD4B Homo sapiens Q5TF39
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 MFSD4B Homo sapiens Q5TF39
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMEM258 Homo sapiens P61165
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 TMEM258 Homo sapiens P61165
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 LY6E Homo sapiens Q16553
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 LY6E Homo sapiens Q16553
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 C19orf18 Homo sapiens Q8NEA5
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 C19orf18 Homo sapiens Q8NEA5
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 C19orf18 Homo sapiens Q8NEA5
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 APH1A Homo sapiens Q96BI3
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 GJB2 Homo sapiens P29033
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 GJB2 Homo sapiens P29033
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 ALG8 Homo sapiens Q9BVK2
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 SYNDIG1 Homo sapiens Q9H7V2
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
MFSD6 Q6ZSS7 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
MFSD6 Q6ZSS7 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
MFSD6 Q6ZSS7 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Herpangina

  • Vesicular Pharyngitis
West Nile Encephalitis

  • West-Nile Encephalitis

  • West Nile Fever

  • West Nile Fever Encephalitis

  • West Nile Fever With Encephalitis

  • West-Nile Fever

  • Encephalitis, West Nile Fever
Salivary Gland Disease

  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos
Tetanus Neonatorum

  • Neonatal Tetanus

  • NNT

  • Trismus Neonatorum

  • Newborn Trismus
Cutaneous Diphtheria

  • Diphtheria Wound Infection
Parotid Disease

  • Parotid Diseases
Orchitis

  • Inflammation Of Testis

  • Orchititis

  • Mumps Orchitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08393 MFSD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MFSD6 VGNC VGNC:74571
Mus musculus MFSD6 MGD MGI:1922925
Felis catus MFSD6 VGNC VGNC:63484
Bos taurus MFSD6 VGNC VGNC:31441
Rattus norvegicus MFSD6 RGD RGD:1562317
Canis familiaris MFSD6 VGNC VGNC:43205
Others MFSD6 NCBI