TMEM258 - transmembrane protein 258 Gene

Also Known as Kud; Kuduk; C11orf10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 746

About TMEM258

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,788,949-61,792,599 (from NCBI)

This gene has 8 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in colon (RPKM 77.0), stomach (RPKM 64.2) and 25 other tissues.

Summary

Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM258 Products (1)

mRNA Protein Name
NM_014206.4 NP_055021.1 transmembrane protein 258

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28716842 GOA
Biological Process GO Annotation Evidence References Source
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
31831667 GOA
involved in protein N-linked glycosylation IMP
IMP: Inferred from mutant phenotype
26472760 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12427278 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26472760 GOA
located in membrane IDA
IDA: Inferred from direct assay
28716842 GOA
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
26472760 GOA
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM258 Protein Structure

Ost5

Ost5: Oligosaccharyltransferase subunit 5 (3 - 79)

  • 0
  • 79 a.a.
Protein Preferred Names Protein Names

transmembrane protein 258

  • UPF0197 transmembrane protein C11orf10

TMEM258 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM258 P61165 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
TMEM258 P61165 ARL6IP1 Homo sapiens Q15041
Validated Y2H
32296183
Intra
TMEM258 P61165 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
TMEM258 P61165 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
TMEM258 P61165 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
TMEM258 P61165 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 20

  • Spinocerebellar Ataxia Type 20

  • SCA20

  • Spinocerebellar Ataxia With Dysphonia

  • Spinocerebellar Ataxia With Spasmodic Cough

  • Chromosome 11q12 Duplication Syndrome, 260-Kb

  • Chromosome 11q12 Duplication Syndrome 260-Kb
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14711 TMEM258 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMEM258 VGNC VGNC:81204
Rattus norvegicus TMEM258 RGD RGD:1560328
Bos taurus TMEM258 VGNC VGNC:36066
Mus musculus TMEM258 MGD MGI:1916288
Others TMEM258 NCBI