STX12 - syntaxin 12 Gene

Also Known as STX13; STX14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23673

About STX12

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,773,219-27,824,443 (from NCBI)

This gene has 5 transcripts (splice variants), 248 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 63.8), fat (RPKM 35.7) and 25 other tissues.

Summary

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; Cholesterol efflux; and protein stabilization. Located in several cellular components, including membrane raft; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. Colocalizes with BLOC-1 complex. [provided by Alliance of Genome Resources, Apr 2022]

STX12 Products (1)

mRNA Protein Name
NM_177424.3 NP_803173.1 syntaxin-12

STX12 Protein Structure

Syntaxin_2

Syntaxin_2: Syntaxin-like protein (30 - 131)

SNARE

SNARE: SNARE domain (183 - 245)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

syntaxin-12

STX12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STX12 Q86Y82 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
33961781
Intra
STX12 Q86Y82 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
28514442
Intra
STX12 Q86Y82 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
26359495
Intra
STX12 Q86Y82 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
STX12 Q86Y82 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
STX12 Q86Y82 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
STX12 Q86Y82 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 STXBP5L Homo sapiens Q9Y2K9
Validated Y2H
32296183
Intra
STX12 Q86Y82 STXBP5L Homo sapiens Q9Y2K9
Y2H Array
32296183
Intra
STX12 Q86Y82 STXBP5L Homo sapiens Q9Y2K9
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
STX12 Q86Y82 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra
STX12 Q86Y82 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
STX12 Q86Y82 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
STX12 Q86Y82 PLPPR2 Homo sapiens Q96GM1
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 PLPPR2 Homo sapiens Q96GM1
Validated Y2H
32296183
Intra
STX12 Q86Y82 PLPPR2 Homo sapiens Q96GM1
Y2H Array
32296183
Intra
STX12 Q86Y82 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
STX12 Q86Y82 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
STX12 Q86Y82 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
STX12 Q86Y82 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
STX12 Q86Y82 AQP8 Homo sapiens O94778
Y2H Array
32296183
Intra
STX12 Q86Y82 AQP8 Homo sapiens O94778
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
STX12 Q86Y82 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
STX12 Q86Y82 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Intra
STX12 Q86Y82 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra
STX12 Q86Y82 MFSD6 Homo sapiens Q6ZSS7
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 MFSD6 Homo sapiens Q6ZSS7
Y2H Array
32296183
Intra
STX12 Q86Y82 SLC66A2 Homo sapiens Q8N2U9
Validated Y2H
32296183
Intra
STX12 Q86Y82 SLC66A2 Homo sapiens Q8N2U9
Y2H Array
32296183
Intra
STX12 Q86Y82 SLC66A2 Homo sapiens Q8N2U9
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
STX12 Q86Y82 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
STX12 Q86Y82 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Validated Y2H
25416956
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Anti Tag CoIP
33961781
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Anti Tag CoIP
28514442
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Y2H Array
25416956
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Y2H Prey Pooling
25416956
Intra
STX12 Q86Y82 SNAP29 Homo sapiens O95721
Anti Tag CoIP
35271311
Intra
STX12 Q86Y82 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
STX12 Q86Y82 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
STX12 Q86Y82 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
STX12 Q86Y82 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
STX12 Q86Y82 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
STX12 Q86Y82 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
STX12 Q86Y82 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
STX12 Q86Y82 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
STX12 Q86Y82 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
STX12 Q86Y82 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
STX12 Q86Y82 STX4 Homo sapiens Q12846
Anti Tag CoIP
28514442
Intra
STX12 Q86Y82 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra
STX12 Q86Y82 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
STX12 Q86Y82 STX4 Homo sapiens Q12846
Anti Tag CoIP
33961781
Intra
STX12 Q86Y82 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
STX12 Q86Y82 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
STX12 Q86Y82 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra
STX12 Q86Y82 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
STX12 Q86Y82 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
STX12 Q86Y82 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
STX12 Q86Y82 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
STX12 Q86Y82 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
STX12 Q86Y82 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
STX12 Q86Y82 ABCA1 Homo sapiens O95477
IF
15469992
Intra
STX12 Q86Y82 ABCA1 Homo sapiens O95477
Anti Bait CoIP
15469992
Intra
STX12 Q86Y82 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
STX12 Q86Y82 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
STX12 Q86Y82 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xia-Gibbs Syndrome

  • Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome

  • XIGIS

  • Mrd25

  • Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome

  • Mental Retardation, Autosomal Dominant 25, Formerly

  • Mrd25, Formerly

  • Autosomal Dominant Mental Retardation 25

  • Autosomal Dominant Intellectual Disability 25

  • Xgs
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13976 STX12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STX12 VGNC VGNC:65807
Canis familiaris STX12 VGNC VGNC:84434
Rattus norvegicus STX12 RGD RGD:620977
Bos taurus STX12 VGNC VGNC:35432
Mus musculus STX12 MGD MGI:1931027
Others STX12 NCBI