GGT7 - gamma-glutamyltransferase 7 Gene

Also Known as GGT4; GGTL3; GGTL5; D20S101

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2686

About GGT7

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,844,720-34,872,856 (from NCBI)

This gene has 4 transcripts (splice variants), 244 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.3), thyroid (RPKM 7.4) and 25 other tissues.

Summary

This gene is a member of a gene family that encodes Enzymes involved in both the metabolism of glutathione and in the transpeptidation of Amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]

GGT7 Products (2)

mRNA	Protein	Name
NM_001351702.2	NP_001338631.1	glutathione hydrolase 7 isoform 2
NM_178026.3	NP_821158.2	glutathione hydrolase 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12270127	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of response to oxidative stress	IMP IMP: Inferred from mutant phenotype	25884624	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12270127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGT7 Protein Structure

G_glu_transpept

0
200
400
600
662 a.a.

Protein Preferred Names	Protein Names
glutathione hydrolase 7	GGT 7

GGT7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GGT7	Q9UJ14	GPR25	Homo sapiens	O00155	Y2H Array	25416956
Intra	GGT7	Q9UJ14	GPR25	Homo sapiens	O00155	Y2H Prey Pooling	25416956
Intra	GGT7	Q9UJ14	GPR25	Homo sapiens	O00155	Validated Y2H	25416956
Intra	GGT7	Q9UJ14	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	25416956
Intra	GGT7	Q9UJ14	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	31515488
Intra	GGT7	Q9UJ14	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	25416956
Intra	GGT7	Q9UJ14	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	25416956
Intra	GGT7	Q9UJ14	MALL	Homo sapiens	Q13021	Y2H Prey Pooling	25416956
Intra	GGT7	Q9UJ14	MALL	Homo sapiens	Q13021	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Glutathionuria	Gamma-Glutamyltransferase Deficiency Ggt Deficiency Gtg Deficiency Gamma-Glutamyltranspeptidase Deficiency Glutathioninuria Gamma-Glutamyl Transpeptidase Deficiency Gamma-Glutamyl Transferase Deficiency Ggt1 Deficiency GLUTH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05406	GGT7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GGT7	VGNC	VGNC:41203
Macaca mulatta	GGT7	VGNC	VGNC:72921
Felis catus	GGT7	VGNC	VGNC:62541
Bos taurus	GGT7	VGNC	VGNC:29346
Mus musculus	GGT7	MGD	MGI:1913385
Rattus norvegicus	GGT7	RGD	RGD:619870
Others	GGT7	NCBI