GPR25 - G protein-coupled receptor 25 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2848

About GPR25

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,872,981-200,874,178 (from NCBI)

This gene has 1 transcript (splice variant), 153 orthologues and 7 paralogues.

Summary

This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

GPR25 Products (1)

mRNA Protein Name
NM_005298.4 NP_005289.2 probable G-protein coupled receptor 25

GPR25 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (56 - 307)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 25

GPR25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR25 O00155 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
GPR25 O00155 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
32296183
Intra
GPR25 O00155 VAPB Homo sapiens Q53XM7
Validated Y2H
25416956
Intra
GPR25 O00155 VAPB Homo sapiens Q53XM7
Y2H Prey Pooling
25416956
Intra
GPR25 O00155 NAALADL2 Homo sapiens Q58DX5
Validated Y2H
25416956
Intra
GPR25 O00155 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
GPR25 O00155 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
GPR25 O00155 CNIH4 Homo sapiens Q9P003
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 CNIH4 Homo sapiens Q9P003
Validated Y2H
32296183
Intra
GPR25 O00155 CNIH4 Homo sapiens Q9P003
Y2H Array
32296183
Intra
GPR25 O00155 GGT7 Homo sapiens Q9UJ14
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 GGT7 Homo sapiens Q9UJ14
Validated Y2H
32296183
Intra
GPR25 O00155 GGT7 Homo sapiens Q9UJ14
Y2H Array
32296183
Intra
GPR25 O00155 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
GPR25 O00155 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
GPR25 O00155 VAPB Homo sapiens O95292
Validated Y2H
32296183
Intra
GPR25 O00155 VAPB Homo sapiens O95292
Y2H Array
32296183
Intra
GPR25 O00155 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
GPR25 O00155 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
GPR25 O00155 IKBIP Homo sapiens Q70UQ0-4
Validated Y2H
32296183
Intra
GPR25 O00155 IKBIP Homo sapiens Q70UQ0-4
Y2H Array
32296183
Intra
GPR25 O00155 IKBIP Homo sapiens Q70UQ0-4
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 RETN Homo sapiens Q9HD89
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 RETN Homo sapiens Q9HD89
Y2H Array
32296183
Intra
GPR25 O00155 RETN Homo sapiens Q9HD89
Validated Y2H
32296183
Intra
GPR25 O00155 ATP6V0E1 Homo sapiens O15342
Validated Y2H
32296183
Intra
GPR25 O00155 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra
GPR25 O00155 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
GPR25 O00155 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
GPR25 O00155 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 SLC35E3 Homo sapiens Q7Z769
Validated Y2H
32296183
Intra
GPR25 O00155 SLC35E3 Homo sapiens Q7Z769
Y2H Array
32296183
Intra
GPR25 O00155 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra
GPR25 O00155 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra
GPR25 O00155 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 GJB1 Homo sapiens P08034
Validated Y2H
32296183
Intra
GPR25 O00155 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
GPR25 O00155 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
GPR25 O00155 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 SHISAL1 Homo sapiens Q3SXP7
Validated Y2H
32296183
Intra
GPR25 O00155 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
GPR25 O00155 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
GPR25 O00155 TPRA1 Homo sapiens Q86W33-2
Validated Y2H
32296183
Intra
GPR25 O00155 TPRA1 Homo sapiens Q86W33-2
Y2H Array
32296183
Intra
GPR25 O00155 TPRA1 Homo sapiens Q86W33-2
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra
GPR25 O00155 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra
GPR25 O00155 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
GPR25 O00155 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 TSPAN12 Homo sapiens O95859
Validated Y2H
32296183
Intra
GPR25 O00155 SLCO4A1 Homo sapiens Q96BD0
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 SLCO4A1 Homo sapiens Q96BD0
Y2H Array
32296183
Intra
GPR25 O00155 SLCO4A1 Homo sapiens Q96BD0
Validated Y2H
32296183
Intra
GPR25 O00155 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
GPR25 O00155 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra
GPR25 O00155 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra
GPR25 O00155 SLC16A7 Homo sapiens O60669
Validated Y2H
32296183
Intra
GPR25 O00155 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
GPR25 O00155 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
GPR25 O00155 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
GPR25 O00155 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
GPR25 O00155 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
GPR25 O00155 CREB3L1 Homo sapiens Q96BA8
Y2H Array
31515488
Intra
GPR25 O00155 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 ATP6V0C Homo sapiens P27449
Validated Y2H
32296183
Intra
GPR25 O00155 ATP6V0C Homo sapiens P27449
Y2H Array
32296183
Intra
GPR25 O00155 ATP6V0C Homo sapiens P27449
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra
GPR25 O00155 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
GPR25 O00155 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
GPR25 O00155 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
GPR25 O00155 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
GPR25 O00155 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra
GPR25 O00155 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra
GPR25 O00155 CREB3L3 Homo sapiens Q68CJ9
Validated Y2H
32296183
Intra
GPR25 O00155 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2196A ELA-32(human) TFA Agonist 99.93% Unkown
HY-RS05697 GPR25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR25 VGNC VGNC:82435
Rattus norvegicus GPR25 RGD RGD:1311611
Macaca mulatta GPR25 VGNC VGNC:73130
Bos taurus GPR25 VGNC VGNC:106757
Canis familiaris GPR25 VGNC VGNC:41427
Mus musculus GPR25 MGD MGI:2686146
Others GPR25 NCBI