MARCHF2 - membrane associated ring-CH-type finger 2 Gene

Also Known as MARCH2; RNF172; HSPC240; MARCH-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51257

Summary

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH Enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Ubiquitous expression in fat (RPKM 20.9), heart (RPKM 12.9) and 25 other tissues.

MARCHF2 Products (7)

mRNA Protein Name
NM_001005415.2 NP_001005415.1 E3 ubiquitin-protein ligase MARCHF2 isoform 1
NM_001005416.2 NP_001005416.1 E3 ubiquitin-protein ligase MARCHF2 isoform 2
NM_001369776.1 NP_001356705.1 E3 ubiquitin-protein ligase MARCHF2 isoform 1
NM_001369777.1 NP_001356706.1 E3 ubiquitin-protein ligase MARCHF2 isoform 1
NM_001369778.1 NP_001356707.1 E3 ubiquitin-protein ligase MARCHF2 isoform 1
NM_001369779.1 NP_001356708.1 E3 ubiquitin-protein ligase MARCHF2 isoform 1
NM_016496.5 NP_057580.3 E3 ubiquitin-protein ligase MARCHF2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17980554 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
14722266 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
17980554 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
29573664 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
14722266 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
32935379 GOA
involved in suppression of viral release by host IMP
IMP: Inferred from mutant phenotype
29573664 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
23818989 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
32935379 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14722266 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14722266 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
32935379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCHF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MARCHF2 Q9P0N8 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
25416956
Intra
MARCHF2 Q9P0N8 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 LDLRAD1 Homo sapiens Q5T700
Y2H Array
31515488
Intra
MARCHF2 Q9P0N8 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TSPO2 Homo sapiens Q5TGU0
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TSPO2 Homo sapiens Q5TGU0
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 PLPPR2 Homo sapiens Q96GM1
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 PLPPR2 Homo sapiens Q96GM1
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 LGR4 Homo sapiens Q9BXB1-2
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 LGR4 Homo sapiens Q9BXB1-2
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 CCL4 Homo sapiens P13236
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 CCL4 Homo sapiens P13236
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
MARCHF2 Q9P0N8 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
MARCHF2 Q9P0N8 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra
MARCHF2 Q9P0N8 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra
MARCHF2 Q9P0N8 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra
MARCHF2 Q9P0N8 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
MARCHF2 Q9P0N8 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra
MARCHF2 Q9P0N8 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
MARCHF2 Q9P0N8 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
MARCHF2 Q9P0N8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
BioID
31142615
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
Confocal
31142615
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
Anti Tag CoIP
31142615
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
MARCHF2 Q9P0N8 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction