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51257

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By Targets:	Apoptosis (1) Casein Kinase (1) Histamine Receptor (1) Isotope-Labeled Compounds (1) MicroRNA (12) Ras (2)
By Research Areas:	Cancer (16) Inflammation/Immunology (1)
Oligonucleotides:	miRNA mimics (3) miRNA agomirs (3) miRNA antagomirs (3) MicroRNAs (12) miRNA inhibitors (3)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173629

RMC-5127	Ras Apoptosis	Cancer
RMC-5127 is a small molecule inhibitor that binds to GTP-targeted KRAS ^G12V, with oral bioavailability and blood-brain barrier permeability. RMC-5127 inhibits the activities of the RAS and MAPK pathways, suppresses the proliferation of KRAS ^G12V-mutant cancer cells and induces their apoptosis. RMC-5127 can be used for the research of KRAS ^G12V-mutant non-small cell lung cancer, pancreatic ductal adenocarcinoma, colorectal cancer and intracranial KRAS ^G12V tumors .

HY-114436

MRTX-1257 5 Publications Verification	Ras	Cancer
MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC₅₀ of 900 pM for KRAS dependent ERK phosphorylation in H358 cells .

HY-178980

APL-5125	Casein Kinase	Cancer
APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC₅₀ of 0.348 nM and a K_i of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer .

HY-114436S

*MRTX-1257-d6*	Isotope-Labeled Compounds	Cancer
MRTX-1257-d₆ is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC₅₀ of 900 pM for KRAS dependent ERK phosphorylation in H358 cells .

HY-R03270

*mmu-miR-5125* mimic**	MicroRNA	Cancer
mmu-miR-5125 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5125 mimic mmu-miR-5125 mimic

HY-RI00161

*hsa-miR-1257* inhibitor**	MicroRNA	Cancer
hsa-miR-1257 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-1257 inhibitor hsa-miR-1257 inhibitor

HY-116208

Dalcotidine KU-1257	Histamine Receptor	Inflammation/Immunology
Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion .

HY-RI03270

*mmu-miR-5125* inhibitor**	MicroRNA	Cancer
mmu-miR-5125 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5125 inhibitor mmu-miR-5125 inhibitor

HY-RI03272A

*mmu-miR-5127* antagomir**	MicroRNA	Cancer
mmu-miR-5127 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5127 antagomir mmu-miR-5127 antagomir

HY-RI03270A

*mmu-miR-5125* antagomir**	MicroRNA	Cancer
mmu-miR-5125 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5125 antagomir mmu-miR-5125 antagomir

HY-R03272

*mmu-miR-5127* mimic**	MicroRNA	Cancer
mmu-miR-5127 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5127 mimic mmu-miR-5127 mimic

HY-R00161

*hsa-miR-1257* mimic**	MicroRNA	Cancer
hsa-miR-1257 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-1257 mimic hsa-miR-1257 mimic

HY-R03272A

*mmu-miR-5127* agomir**	MicroRNA	Cancer
mmu-miR-5127 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5127 agomir mmu-miR-5127 agomir

HY-R03270A

*mmu-miR-5125* agomir**	MicroRNA	Cancer
mmu-miR-5125 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5125 agomir mmu-miR-5125 agomir

HY-RI00161A

*hsa-miR-1257* antagomir**	MicroRNA	Cancer
hsa-miR-1257 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1257 antagomir hsa-miR-1257 antagomir

HY-RI03272

*mmu-miR-5127* inhibitor**	MicroRNA	Cancer
mmu-miR-5127 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5127 inhibitor mmu-miR-5127 inhibitor

HY-R00161A

*hsa-miR-1257* agomir**	MicroRNA	Cancer
hsa-miR-1257 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1257 agomir hsa-miR-1257 agomir

*MRTX-1257-d6*
MRTX-1257-d₆ is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC₅₀ of 900 pM for KRAS dependent ERK phosphorylation in H358 cells .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Bovine (1) Rat (2) Mouse (2) Monkey (1) Dog (1) Pig (1)
Application:	IHC-P (3) ICC/IF (2) IF-Tissue (1) IP (1) IHC-F (1) WB (4) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81512

	uPAR Antibody (YA1257) U-PAR; Monocyte activation antigen Mo3; CD87	IHC-P	Human
	uPAR Antibody (YA1257) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to uPAR.

HY-P85465

	SYCP3 Antibody (YA5157) SYCP3; SCP3; Synaptonemal complex protein 3; SCP-3	WB	Human
	SYCP3 Antibody (YA5157) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYCP3.

HY-P85435

	hnRNP U Antibody (YA5127) HNRNPU; HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; Scaffold attachment factor A; SAF-A; p120; pp120	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	hnRNP U Antibody (YA5127) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to hnRNP U.

HY-P85433

	Hsc70 Interacting Protein Antibody (YA5125) ST13; AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tum	WB, IHC-P, ICC/IF	Human, Bovine, Dog, Pig
	Hsc70 Interacting Protein Antibody (YA5125) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsc70 Interacting Protein.

HY-P85565

	Switch Associated Protein 70 Antibody (YA5257) KIAA0640; 70kDa; AV235546; FLJ39540; HSPC321; SWA 70 protein; SWAP 70; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch associated protein 70; Switch-associated protein 70; SWP70_HUMAN.	WB, IP	Human, Mouse, Rat, Monkey
	Switch Associated Protein 70 Antibody (YA5257) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Switch Associated Protein 70.

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Cat. No.	Product Name		Classification

HY-R03270

*mmu-miR-5125* mimic**		MicroRNAs miRNA mimics
mmu-miR-5125 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI00161

*hsa-miR-1257* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-1257 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03270

*mmu-miR-5125* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-5125 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03272A

*mmu-miR-5127* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-5127 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03270A

*mmu-miR-5125* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-5125 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03272

*mmu-miR-5127* mimic**		MicroRNAs miRNA mimics
mmu-miR-5127 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R00161

*hsa-miR-1257* mimic**		MicroRNAs miRNA mimics
hsa-miR-1257 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03272A

*mmu-miR-5127* agomir**		MicroRNAs miRNA agomirs
mmu-miR-5127 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03270A

*mmu-miR-5125* agomir**		MicroRNAs miRNA agomirs
mmu-miR-5125 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00161A

*hsa-miR-1257* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-1257 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03272

*mmu-miR-5127* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-5127 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R00161A

*hsa-miR-1257* agomir**		MicroRNAs miRNA agomirs
hsa-miR-1257 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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