2206736-04-9
2206736-04-9
Chemical Structure
MRTX-1257
- CAS No.: 2206736-04-9
- Formula:C33H39N7O2
- Molecular Weight:565.71
IUPAC Name: 2-((S)-1-acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile
InChIKey: YRYQLVCTQFBRLD-UIOOFZCWSA-N
SMILES: N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1
Biological Activity: MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MRTX-1257 | 99.71% | MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. | ||||||||||||||||||||
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MRTX-1257-d6 | MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. | |||||||||||||||||||||
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References
Keywords
